Polyamine metabolism and interconversion in NIH 3T3 and ras-transfected NIH 3T3 cells |
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| Authors: | R Pakala M Kreisel U Bachrach |
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| Affiliation: | Department of Molecular Biology, Hebrew University-Hadassah Medical School, Jerusalem, Israel. |
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| Abstract: | The effect of transfection of NIH 3T3 cells by the human ras (c-Ha-ras-1) oncogene on uptake, interconversion, and excretion of polyamines was studied. Uptake and interconversion of spermidine were higher in the ras-transfected cells. Acetylpolyamines were excreted into the medium by the ras-transfected cells, whereas they were retained by NIH 3T3 cells. In addition to acetylpolyamines, some unknown polyamine conjugates occurred in the ras-transfected cells. |
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