实验动物屏障环境常用消毒药品皮肤毒性实验

目的观察动物破损皮肤短期内接触消毒药品所产生的毒性反应。方法利用2％戊二醛、0．2％过氧乙酸、2％过氧乙酸、0．2％次氯酸钠对豚鼠进行人为皮肤破损毒性实验，观察豚鼠全身中毒表现和死亡情况。结果2％戊二醛给药后出现红肿、出血点，4d后出现脱皮现象，5d红肿消失，并伴有棕黄色着色性；2％过乙酸给药后出现轻度水肿，3d后症状消失；0．2％过乙酸和0．2％次氯酸钠均未出现毒性反应。结论2％戊二醛、2％过乙酸对动物和工作人员有毒性作用。

Skin Toxicity of Common Disinfectants to Laboratory Animals in Barrier Environment

Objective To observe the toxic response caused by short time contact with some common disinfectants to the skin in laboratory animals. Methods Carries on the artificial skin breakage toxicity experiment using 2% glutaraldehyde, 0.2% and 2 % poracetic acid and 0.2 % sodium hypochlorite were applied to skin shaving wound in guinea pigs, and toxic changes and death of the animals were observed. Results 2 % gluaraldehyde caused erythema, edema and hemorrhagic spots. Desquamatlon occurred after 4 days and the erythema disappeared after 5 days, with a brownish discoloration left. 2% poracetic acid caused slight edema of the skin which disappoared after 3 days. 0.2 % poracetic acid and 0.2 % sodium hypochlorite did not cause any discernible skin toxic reaction. Conclusions 2 % glutarialdehyde and 2 % poracetic acid are toxic to the skin in animals and humans.