Distribution of neuropeptide Y immunoreactivity in the rat basal ganglia: effects of excitotoxin lesions to caudate-putamen |
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| Authors: | M J Christie P M Beart B Jarrott C Maccarrone |
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| Institution: | 1. Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil;2. Departamento de Bioquímica, Instituto de Química, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil;3. Instituto Nacional de Ciência e Tecnologia - Entomologia Molecular, Rio de Janeiro, RJ, Brazil;4. Tick-Pathogen Transmission Unit, Laboratory of Bacteriology, National Institute of Allergy and Infectious Diseases, Hamilton, MT, USA;5. Vector Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, Rockville, MD, USA;6. Institut de Neurosciences Cognitives et Intégratives d''Aquitaine, UMR 5287 CNRS, Université de Bordeaux, Bordeaux, France;7. Faculdade de Veterinária, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil;1. Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Victoria, Australia;2. Department of Biochemistry & Molecular Biology, The University of Melbourne, Victoria, Australia;3. School of Chemistry, The University of Melbourne, Victoria, Australia;4. Department of Biology, University of Winnipeg, Winnipeg, Manitoba, R3E 2H9, Canada;5. Department of Immunology, University of Toronto, Toronto, Canada;6. Reproductive Biology Group, Division of Developmental Biology, Department of Biology, Faculty of Science, Utrecht University, Utrecht, The Netherlands;7. Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Victoria, Australia |
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| Abstract: | The distribution of neuropeptide Y-like immunoreactivity (NPY-LI) within the rat basal ganglia was studied using microdissection with a sensitive radioimmunoassay, and excitotoxin lesions were made in an attempt to characterise the neurones containing NPY in this brain area. Immunoreactivity was unevenly distributed in the basal ganglia of control rats, with concentrations in the caudate-putamen (CP) and nucleus accumbens being appreciably higher than those found in the globus pallidus and substantia nigra (SN). Within the CP, immunoreactivity was concentrated in caudal and extreme rostral aspects. N-Methyl-D-aspartate lesions of the rostral CP significantly reduced immunoreactivity in this area, whilst levels in other regions of the basal ganglia were unaffected. Neurones containing NPY-LI are likely to be intrinsic to the CP and do not appear to project to the globus pallidus or SN. |
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