| 盐酸曲美他嗪择时渗透泵控释片的制备及含量测定 |
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| 引用本文： | 杨楚颢,刘辉,张芸,都胜男,卢立. 盐酸曲美他嗪择时渗透泵控释片的制备及含量测定[J]. 中国药师, 2013, 0(12): 1781-1784 |
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| 作者姓名： | 杨楚颢 刘辉 张芸 都胜男 卢立 |
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| 作者单位： | 南方医科大学武汉临床医学院2012级研究生 武汉 430070；广州军区武汉总医院药剂科；;广州军区武汉总医院药剂科；;广州军区武汉总医院药剂科；湖北中医药大学药学院2011级研究生；;广州军区武汉总医院药剂科；湖北中医药大学药学院2011级研究生；;广州军区武汉总医院药剂科；南方医科大学武汉临床医学院2011级研究生 |
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| 基金项目： | 国家“十二五”科技重大专项经费资助课题(编号：2013ZX09J13109-05C) |
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| 摘 要： | 目的：建立盐酸曲美他嗪择时渗透泵控释片中盐酸曲美他嗪的高效液相色谱含量测定方法。方法：采用Dikma Diamonsil C18色谱柱（250 mm×4.6 mm,5μm）,以0.02 mol·L-1乙酸铵（含0.5%三乙胺）-甲醇（50：50）为流动相,流速为1.0 ml·min-1,检测波长为232 nm.进样量20μl。结果：在此色谱条件下,盐酸曲美他嗪浓度与峰面积在6.016.8μg·ml-1内线性关系良好,r=0.999 5,平均回收率为99.6%,RSD为1.04%（n=9）。结论：本方法灵敏度高,快速准确,可用于盐酸曲美他嗪择时控释片的质量控制。
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| 关 键 词： | 盐酸曲美他嗪 择时 渗透泵 控释片 含量测定 高效液相色谱 |
| 收稿时间： | 2013-06-19 |
| 修稿时间： | 2013-08-24 |
Preparation and Determination of Trimetazidine Dihydrochloride Pulsatile Osmotic Pump Controlled Release Tablets |
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| Yang Chuhao,Liu Hui,Zhang Yun,Du Shengnan and Lu Li. Preparation and Determination of Trimetazidine Dihydrochloride Pulsatile Osmotic Pump Controlled Release Tablets[J]. China Pharmacist, 2013, 0(12): 1781-1784 |
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| Authors: | Yang Chuhao Liu Hui Zhang Yun Du Shengnan Lu Li |
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| Affiliation: | Postgraduate 2012, Clinical Medical College in Wuhan, Southern Medical University, Wuhan 430070, China; Department of Pharmacy, Wuhan General Hospital of Guangzhou Military Command;;Department of Pharmacy, Wuhan General Hospital of Guangzhou Military Command;;Department of Pharmacy, Wuhan General Hospital of Guangzhou Military Command; Postgraduate 2011, College of Pharmacy, Hubei University of Chinese Medicine;;Department of Pharmacy, Wuhan General Hospital of Guangzhou Military Command; Postgraduate 2011, College of Pharmacy, Hubei University of Chinese Medicine;;Department of Pharmacy, Wuhan General Hospital of Guangzhou Military Command; Postgraduate 2011,Clinical Medicine College in Wuhan, Southern Medical University |
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| Abstract: | Objective;To eslablish an HPLC method for the determination of trimetazidine dihydrochloride pulsatile controlled release tablets.Method：A Dikma Diamonsil C18 column（250 mm×4.6 mm,5μm）was used,the mobile phase consisted of0.02 mol ？ L-1 ammonium acetate（including 0.5%triethylamine）-methanol（50：50） with a flow rate of 1.0 ml？min-1,the detection wavelength was 232nm,and the injection volume was 20μl.Result：The linear range of trimetazidine dihydrochloride was 6.0-16.8 μg？ ml-1（r=0.999 5）.The recovery was 99.6%with RSD of 1.04%（n =9）.Conclusion;The method is sensitive,rapid and accurate,and can be used in the quality control of trimetazidine dihydrochloride pulsatile controlled release tablets. |
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| Keywords: | Trimetazidine dihydrochloride Pulsatile Osmotic pump Controlled release tablets Determination HPLC |
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