| GC-MS法对药用辅料1,2-丙二醇未知杂质的定性研究 |
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| 引用本文： | 彭琳,刘雁鸣,龙海燕,范硕.GC-MS法对药用辅料1,2-丙二醇未知杂质的定性研究[J].中国药师,2013(12):1817-1819. |
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| 作者姓名： | 彭琳 刘雁鸣 龙海燕 范硕 |
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| 作者单位： | 湖南药用辅料检验检测中心 长沙 410014；;湖南药用辅料检验检测中心 长沙 410014；;湖南药用辅料检验检测中心 长沙 410014；;湖南省食品药品安全信息中心 |
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| 摘 要： | 目的：对1,2-丙二醇样品中未知杂质进行质谱确证。方法：运用GC-MS法,采用AB-INOWAX毛细管柱（30 m×0.25 mm,0.25μm）;柱温：起始温度60℃,保持3 min,以10℃·min-1升温至220℃,保持4 min;EI源温度：230℃。结果：样品中未知杂质实为已知杂质一缩二丙二醇的异构体。结论：该方法简便、快速、灵敏度高,可用于1,2-丙二醇中有关物质的定性检测。
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| 关 键 词： | 药用辅料 1 2-丙二醇 杂质 气相色谱-质谱联用 |
| 收稿时间： | 2013/5/25 0:00:00 |
| 修稿时间： | 2013/8/11 0:00:00 |
Qualitative Determination of Unknown Substances in Propylene Glycol by GC-MS |
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| Peng Lin,Liu Yanming,Long Haiyan and Fan Shuo.Qualitative Determination of Unknown Substances in Propylene Glycol by GC-MS[J].China Pharmacist,2013(12):1817-1819. |
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| Authors: | Peng Lin Liu Yanming Long Haiyan and Fan Shuo |
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| Institution: | 1. Hunan Pharmaceutical Excipients Testing and Inspection Center, Changsha 410014, China;2. Hunan Provincial Food and Drug Safety Information Center) |
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| Abstract: | Objective：To establish a GC-MS method to identify the related unknown suhslances in propylene glycol.Method：A GC-MS method using an AB-INOWAX capillary column（30 m×0.25 mm,0.25 μm）with temperature programming was employed. The initial temperature was 60℃,kept for 3min,risen to 220℃ with a rate of 10℃ ？min-1,and kept for 4min.The temperature of ion source was 230℃.Result：The unknown substances in four samples were the isomerides of dipropylene glycol.Conclusion：The method is fast,simple and reproducible,and suitable for the identification of the related substances in propylene glycol. |
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| Keywords: | Pharmaceutical adjuvants Propylene glycol Related substances GC-MS |
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