成都市健康体检成人非酒精性脂肪肝流行病学研究

目的探讨成都市成人健康体检非酒精性脂肪肝（NAFLD）流行病学及危险因素分析，并为NAFLD防治提供可靠依据。方法收集2007年6月至2008年2月成都市成人健康体检资料共计12152例，分别统计年龄、性别、体重指数、血糖、胆固醇、三酰甘油（TG）、B超结果。通过问卷方式对参检者进行生活、工作方式问卷调查。结果成都市成人健康体检NAFLD患病率12．3％，男性和女性分别为15．5％和7．0％。无论是男性或是女性，均随年龄增长而增加，患病高峰年龄段为51—60岁，而女性61～80岁之间为高发年龄段；在60岁之前男性患病率显著高于女性，两者比较差异有统计学意义，而60岁之后两者患病率差异无统计学意义。男性患者从事脑力劳动、习惯咸食、吸烟及不运动者脂肪肝患病率明显增高；而女性患者主要与工作压力不大、习惯咸食有关。NAFLD常见的伴随疾病为超重或肥胖、其次分别为高TG血症、高胆固醇血症、高血糖。结论成都市健康体检人群NAFLD患病率男性明显高于女性，低于国内发达城市，高于农村社区居民，与陕甘两省患病率相似；NAFLD的患病率与年龄有非常明显的关系；NAFLD主要危险因素为不良的生活和工作方式，不同性别其危险因素不尽相同。

Nonalcoholic fatty liver disease among adult health examination participants in Chengdu

Objective To investigate the prevalence and major risk factors of nonalcoholic fatty liver disease （NAFLD） among adult health examination participants in Chengdu to provide reliable evidence for the control and prevention of the disease. Methods The clinical data, including age, gender, body mass index,blood glucose ,total cholesterol, triglyceride, and B-ultrasound, were available in 12 152 adults health examination participants in Chengdu from June 2007 to February 2008. Questionnaire survey for details in life or work style was conducted. Results The prevalence rate of NAFLD of the subjects was 12. 3% . The incidence of NAFLD in men was significantly higher than that in women （ 15.5% and 7.0% , respectively; P 〈0. 001 ）. NAFLD was correlated to age and gender. The highest incidence was found in 51450 years group in men and 61-80 years group in women. In 〈 60 years group, the prevalence of NAFLD in men was significantly higher than that in women. However, in 〉 60 years group, no different incidence was observed. The morbidity rate of NAFLD in men was significantly increased in those preferred mental labors, salty food, smoking, and no activities. The higher prevalence rate of NAFLD in women was correlated with light working pressure and salty food. The major accompaniment diseases of NAFLD were overweight or obesity, hyperlipemia, and fasting hyperglycemia. Conclusion The prevalence rate of NAFLD among adult health examination participants. The rate of NAFLD in men was significantly higher than that in women in Chengdu. NAFLD may be related with age, and its major risk factors include unhealthy life and work style.