| 系统性硬化的生物标记物 |
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| 引用本文： | 莫红楠,李梦涛,曾小峰.系统性硬化的生物标记物[J].中华临床免疫和变态反应杂志,2010(4):300-306. |
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| 作者姓名： | 莫红楠 李梦涛 曾小峰 |
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| 作者单位： | 中国医学科学院北京协和医学院北京协和医院风湿免疫科,北京100032 |
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| 基金项目： | 欧洲抗风湿病联盟硬皮病试验研究组 首都医学发展科研基金重点支持项目（2009-2003）; 中华医学会临床医学科研专项资金（08010270105）; 北京协和医院青年科研基金（I604900） |
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| 摘 要： | 系统性硬化(systemic sclerosis,SSc)是一种复杂的结缔组织病,其发病机制与纤维化、微血管功能失调和自身免疫有关。SSc患者除皮肤受累外,往往还会有胃肠道、肺脏等内脏器官的损害。最近研究发现的一系列蛋白和基因为解释其病因提供了新的依据,而包括自身抗体在内的一些血清蛋白,对患者的诊断和病情评估有较大的帮助。
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| 关 键 词： | 系统性硬化 生物标记物 |
New Insights of Systemic Sclerosis Associated Biomarkers |
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| MO Hong-nan,LI Meng-tao,ZENG Xiao-feng.New Insights of Systemic Sclerosis Associated Biomarkers[J].Chinese Journal of Allergy and Clinical Immunology,2010(4):300-306. |
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| Authors: | MO Hong-nan LI Meng-tao ZENG Xiao-feng |
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| Institution: | #(Department of Rheumatology,Peking Union Medical College Hospital,Chinese Academy of Medical Science ＆ Peking Union Medical College,Beijing 100032,China) |
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| Abstract: | Systemic sclerosis（SSc） is one kind of complicated connective tissue disease.Its pathogenesis is related to fibrosis,dysfunction of capillary vessel and autoimmunity.Besides the involvement of skin,patients with SSc also have a tendency to suffer from lesions of internal organs such as gastroin-testinal tract and lung.Recent studies have discovered some proteins and genes as new evidences to elucidate the etiology of the disease.Some seral proteins,including the autoantibody,are also considered a great help on the diagnosis and severity assessment of patients with SSc. |
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| Keywords: | systemic sclerosis biomarker |
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