系统性硬化症的肾脏表现

系统性硬化症肾脏受累的主要类型包括硬皮病肾危象、慢性肾疾病和炎症性肾损害,肾脏受累仍然是硬皮病的主要并发症之一。硬皮病肾危象需要早期诊断,积极使用血管紧张素转化酶抑制剂。尽管使用血管紧张素转化酶抑制剂,硬皮病肾危象患者的预后仍差。系统性硬化症患者中存在抗中性粒细胞胞浆抗体相关血管炎。任何没有高血压的硬皮病患者出现肾功能损害或明显蛋白尿应考虑行肾活检。

Renal Manifestations of Systemic Sclerosis

The main patterns of renal disorder in systemic sclerosis include scleroderma renal crisis, chronic kidney disease and inflammatory renal disorders.Renal involvement remains a major complication of scleroderma.Scleroderma renal crisis requires prompt diagnosis and treatment with angiotensin-converting enzyme inhibitors.Long-term outcome after renal crisis remains poor despite the use of angiotensin-converting enzyme inhibitors.ANCA-associated vasculitis is recognized in systemic sclerosis.Any cases of renal impairment or significant proteinuria in the absence of hypertension require consideration for renal biopsy.