男性2型糖尿病患者骨密度变化及相关因素分析

目的探讨男性2型糖尿病患者骨密度变化及相关因素。方法应用双能X线测定了118例男性2型糖尿病患者和53例对照组L2-L4及股骨近端骨密度，根据骨密度将2型糖尿病患者分为无骨质疏松组（DM—A组）和并发骨质疏松组（DM—B组），测定两组患者的年龄、体重指数、病程、空腹血糖、空腹胰岛素、空腹C肽、糖化血红蛋白、尿白蛋白排泄率。结果男性2型糖尿病患者股骨颈的BMD较健康对照组显著下降（P〈0．01）；DM-B组病程、BMI、HbAlc、FPG、UAER与DM-A组差异显著（P〈0．01，P〈0．05）。结论男性2型糖尿病患者BMI低、血糖控制不良及肾脏损害时更易发生骨质疏松。

A study on the changes of BMD and its affecting factors in male patients with type 2 diabetes mellitus

Aim To investigate the changes of bone mineral density and its affecting factors in male patients with type 2 diabetes mellitus. Methods Dual energy X-ray absorptimmetry was used to measure the BMD of lumbar spines （L2 - L4 ） and proxi-mal femur in 118 male patients with type 2 diabetes and 53 cases of normal control. According to BMD ,T2DM were divided totwo groups（ DM-A and DM- B）. Fasting plasma glucose , fasting plasma insulin , fasting plasma C-peptide , glycated hemoglobin , urine albumin execretim rate were compared between two groups. Results BMD of femoral neck in diabetic patients were significantly lower than that of the control （P 〈 0. 05 ）. There were significant difference of BMI, HbAcl, UAER and duration of the disease between DM-A group and DM-Bgroup. Conclusion Male diabetic patients with low BMI,high HbAcl and renal damage are prone to osteoporosis.