Alleviation of capsular formations on silicone implants in rats using biomembrane-mimicking coatings |
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| Authors: | Ji Ung Park Jiyeon Ham Sukwha Kim Ji-Hun Seo Sang-Hyon Kim Seonju Lee Hye Jeong Min Sunghyun Choi Ra Mi Choi Heejin Kim Sohee Oh Ji An Hur Tae Hyun Choi Yan Lee |
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| Affiliation: | 1. Department of Plastic and Reconstructive Surgery, Seoul National University Boramae Hospital, 5 Gil 20, Boramae-ro, Dongjak-Gu, Seoul 156-707, Republic of Korea;2. Department of Chemistry, College of Natural Sciences, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-747, Republic of Korea;3. Department of Plastic and Reconstructive Surgery, Institute of Human-Environment Interface Biology, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-Gu, Seoul 110-744, Republic of Korea;4. Department of Organic Materials, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kanda-Surugadai, Chiyoda, Tokyo 101-0062, Japan;5. Department of Internal Medicine, Keimyung University Dongsan Medical Center, 56 Dalseong-ro, Jung-Gu, Daegu 700-712, Republic of Korea;6. Biomedical Research Institute, Seoul National University Hospital, 101 Daehak-ro, Jongno-Gu, Seoul 110-744, Republic of Korea;g Department of Biostatics, Seoul National University Boramae Hospital, 5 Gil 20, Boramae-ro, Dongjak-Gu, Seoul 156-707, Republic of Korea;h Department of Internal Medicine, School of Medicine, Yeungnam University, 280 Daehak-ro, Gyeongsan-si, Gyeongsangbook-do 712-749, Republic of Korea |
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| Abstract: | Despite their popular use in breast augmentation and reconstruction surgeries, the limited biocompatibility of silicone implants can induce severe side effects, including capsular contracture – an excessive foreign body reaction that forms a tight and hard fibrous capsule around the implant. This study examines the effects of using biomembrane-mimicking surface coatings to prevent capsular formations on silicone implants. The covalently attached biomembrane-mimicking polymer, poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC), prevented nonspecific protein adsorption and fibroblast adhesion on the silicone surface. More importantly, in vivo capsule formations around PMPC-grafted silicone implants in rats were significantly thinner and exhibited lower collagen densities and more regular collagen alignments than bare silicone implants. The observed decrease in α-smooth muscle actin also supported the alleviation of capsular formations by the biomembrane-mimicking coating. Decreases in inflammation-related cells, myeloperoxidase and transforming growth factor-β resulted in reduced inflammation in the capsular tissue. The biomembrane-mimicking coatings used on these silicone implants demonstrate great potential for preventing capsular contracture and developing biocompatible materials for various biomedical applications. |
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| Keywords: | Foreign body reaction Silicone Surface modification Phosphorylcholine Capsular contracture |
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