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| KAI1和nm23与人黑色素瘤细胞转移潜能的相关性 | |
| 引用本文： | 李珊珊,方伟岗,任秀花,闫爱华,沈琼. KAI1和nm23与人黑色素瘤细胞转移潜能的相关性[J]. 郑州大学学报(医学版), 2000, 35(2): 105-107 |
| 作者姓名： | 李珊珊 方伟岗 任秀花 闫爱华 沈琼 |
| 作者单位： | 1. 河南医科大学第一附属医院病理科,河南省肿瘤病理学重点实验室,郑州,450052 2. 北京医科大学病理系,北京,100083 3. 河南医科大学癌前期研究室,郑州,450052 |
| 基金项目： | 国家博士研究生科研项目，， |
| 摘 要： | 目的:探讨肿瘤转移抑制基因KAI1和nm23与人黑色素瘤细胞转移潜能的关系.方法:应用Northern blot杂交检测不同转移潜能人黑色素瘤细胞中KAI1和nm23基因的表达.结果:4种不同转移潜能的人黑色素瘤细胞中(WM35,WM451,WM983a,WM1341b),KAI1 mRNA和nm23 mRNA均有表达且表达量基本一致,KAI1在4种细胞中的积分光密度值分别为0.1798,0.1800,0.1501,0.1582;nm23分别为1.0428,1.0607,1.0141,1.0754.结论:KAI1基因与nm23基因的表达降低与人黑色素瘤的浸润转移无关. |
| 关 键 词： | 基因 抑制 肿瘤转移 黑色素瘤 KAI1基因 nm23基因 |
| 修稿时间： | 1999-12-25 |
Study on correlation of KAI1 and nm23 expressions with human melanoma metastasis |
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| LI Shanshan,FANG Weigang,REN Xiuhua,YAN Aihua,SHEN Qiong. Study on correlation of KAI1 and nm23 expressions with human melanoma metastasis[J]. Journal of Zhengzhou University: Med Sci, 2000, 35(2): 105-107 | |
| Authors: | LI Shanshan FANG Weigang REN Xiuhua YAN Aihua SHEN Qiong |
| Affiliation: | LI Shanshan(Department of Pathology,the First Affiliated Hospital,Henan Medical University,Zhengzhou450052)FANG Weigang(Department of Pathology,Beijing Medical University,Beijing 100083)REN Xiuhua,YAN Aihua,SHEN Qiong(Department of Precancerous Studies,Henan Medical University,Zhengzhou 450052) |
| Abstract: | Aim:To investigate the correlation of tumor metastasis suppressor gene KAI1, nm23 with metastatic potential of human melanoma cell lines Methods:Expressions of KAI1 gene and nm23 gene in human melanoma cell lines with different metastasis potential were studied by Northern blot hybridization Results:KAI1 mRNA and nm23 mRNA all expressed in four human melanoma cell lines (WM35, WM451, WM983a, WM1341b) and no difference in expression levels were observed in these cancer cell lines(integral light density values in KAI1 gene are 0 179 8, 0 180 0, 0 150 1, 0 158 2 respectively and in nm23 gene are 1 042 8, 1 060 7, 1 014 1, 1 075 4 respectively) Conclusion:Reduced KAI1 and nm23 expressions may be no association with enhanced potential in human melanoma cells |
| Keywords: | neoplasm metastasis gene suppressor neoplasm KAI1 nm23 |
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