苏子降气汤结合机械通气治疗慢性阻塞性肺疾病伴呼吸衰竭临床研究

目的：观察苏子降气汤结合机械通气治疗慢性阻塞性肺疾病伴呼吸衰竭的临床疗效。方法：选择82 例慢性阻塞性肺疾病伴呼吸衰竭患者作为研究对象，采用随机数字表法分为对照组和观察组各 41 例。在支持治疗的基础上，对照组给予机械通气治疗，观察组给予苏子降气汤结合机械通气治疗。评价 2 组临床疗效，比较 2 组治疗前后生命体征、肺功能指标及炎症因子水平。结果：观察组总有效率为 97.56%，高于对照组85.37%（P＜0.05）。治疗后，2 组呼吸频率、心率较治疗前降低（P＜0.05），且观察组体温、呼吸频率、心率低于对照组（P＜0.05）。治疗后，2 组第 1 秒用力呼气容积（FEV1 ）、用力肺活量（FVC）、FEV1/FVC 较治疗前升高（P＜0.05），且观察组 FEV1、FVC、FEV1/FVC 高于对照组（P＜0.05）。治疗后，2 组降钙素原（PCT）、肿瘤坏死因子-α（TNF-α）、白细胞介素-4（IL-4）水平较治疗前降低（P＜0.05），且观察组 PCT、TNF-α、IL-4 水平低于对照组（P＜0.05）。结论：苏子降气汤结合机械通气治疗慢性阻塞性肺疾病伴呼吸衰竭患者，可提高临床疗效，改善患者生命体征，提高肺功能，缓解炎症反应。

ClinicalStudyonSuziJiangqiDecoctionCombinedwithMechanicalVentilationforChronicObstructivePulmonaryDiseaseComplicatedwithRespiratoryFailure

Abstract：Objective：To observe the clinical effect of the therapy of Suzi Jiangqi Decoction combinedwith mechanical ventilation on chronic obstructive pulmonary disease complicated with respiratory failure.Methods： A total of 82 patients with chronic obstructive pulmonary disease complicated with respiratoryfailure were selected as the study subjects and divided into the control group and the observation groupaccording to the random number table method， with 41 cases in each group. Based on supportivetreatment，the control group was treated with mechanical ventilation and the observation group was givenSuzi Jiangqi Decoction combined with mechanical ventilation for treatment. The clinical effects in the twogroups were evaluated；the vital signs and levels of lung function indexes and inflammatory factors werecompared before and after treatment between the two groups. Results： The total effective rate was97.56% in the observation group， higher than that of 85.37% in the control group (P＜0.05). Aftertreatment，the breathing rate and heart rate in the two groups were decreased when compared with thosebefore treatment (P＜0.05)，and the temperature，breathing rate and heart rate in the observation groupwere lower than those in the control group (P＜0.05). After treatment，the force expiratory volume in onesecond (FEV1)，forced vital capacity (FVC) and FEV1/FVC in the two groups were increased when comparedwith those before treatment (P＜0.05)， and the FEV1， FVC and FEV1/FVC in the observation group werehigher than those in the control group (P＜0.05). After treatment，the levels of procalcitonin (PCT)，tumornecrosis factor-α (TNF-α) and interleukin-4 (IL-4) in the two groups were decreased when compared withthose before treatment (P＜0.05)， and the above three levels in the observation group were lower thanthose in the control group (P＜0.05). Conclusion： The therapy of Suzi Jiangqi Decoction combined withmechanical ventilation can enhance the clinical effect on patients with chronic obstructive pulmonarydisease complicated with respiratory failure，improve the vital signs of patients and the lung function，andmitigate the inflammatory responses.