玉屏风颗粒联合粉尘螨滴剂舌下脱敏治疗小儿变应性鼻炎肺脾气虚证临床研究

目的：观察玉屏风颗粒联合粉尘螨滴剂舌下脱敏治疗小儿变应性鼻炎肺脾气虚证的临床疗效。方法：选择90 例变应性鼻炎肺脾气虚证患儿为研究对象，按随机数字表法分为观察组和对照组各45 例。对照组给予粉尘螨滴剂舌下脱敏治疗，观察组在对照组基础上给予玉屏风颗粒冲服。1 周为1 个疗程，连续治疗6 个疗程。比较2 组临床疗效、鼻部症状评分、体液免疫功能指标及炎性因子水平。结果：观察组总有效率为97.78%，高于对照组86.67% （P＜0.05）。治疗后，2 组鼻塞、鼻痒、喷嚏、流涕评分均较治疗前降低（P＜0.05），且观察组各项评分均低于对照组（P＜0.05）。治疗后，2 组血清免疫球蛋白M （IgM）、免疫球蛋白G（IgG） 水平高于治疗前，免疫球蛋白E（IgE） 水平低于治疗前（P＜0.05）；且观察组IgM、IgG 水平高于对照组，IgE 水平低于对照组（P＜0.05）。治疗后，2 组血清白细胞介素-4（IL-4）、白细胞介素-13（IL-13）、血管细胞黏附因子-1（VCAM-1） 水平均较治疗前降低（P＜0.05），且观察组血清IL-4、IL-13、VCAM-1 水平均低于对照组（P＜0.05）。结论：玉屏风颗粒联合粉尘螨滴剂舌下脱敏治疗小儿变应性鼻炎肺脾气虚证的疗效显著，有利于改善患儿临床症状，提高机体免疫力，减轻炎症反应。

Clinical Study on Yupingfeng Granules Combined with Sublingual Desensitizationwith Dermatophagoides Farinae Drops for Allergic Rhinitis in Children with Syndromeof Lung-Spleen Qi Deficiency

Abstract： Objective： To observe the clinical effect of the therapy of Yupingfeng Granules combinedwith sublingual desensitization with Dermatophagoides Farinae Drops for children allergic rhinitis withsyndrome of lung-spleen qi deficiency. Methods：A total of 90 children with allergic rhinitis with syndromeof lung-spleen qi deficiency were selected as the study objects and divided into the observation group andthe control group according to random number table method， with 45 cases in each group. The controlgroup was given sublingual desensitization with Dermatophagoides Farinae Drops， and the observationgroup was additionally given Yupingfeng Granules based on the treatment of the control group. Thetreatment lasted for six courses， one week being a course. The clinical effects， nasal symptom scores，humoral immune function indexes and inflammatory factors were compared between the two groups.Results：The total effective rate was 97.78% in the observation group，higher than that of 86.67% in thecontrol group (P＜0.05). After treatment， the scores of nasal congestion， nasal itchiness， sneezing andrunny nose in the two groups were decreased when compared with those before treatment (P＜0.05)，andthe above scores in the observation group were lower than those in the control group (P＜0.05). Aftertreatment， the levels of serum immunoglobulin M (IgM) and immunoglobulin G (IgG) in the two groupswere increased when compared with those before treatment，and the immunoglobulin E (IgE) levels werelower than those before treatment (P＜0.05)；the IgM and IgG levels in the observation group were higherthan those in the control group，and the IgE level was lower than that in the control group (P＜0.05). Aftertreatment， the serum levels of interleukin- 4 (IL- 4)， interleukin- 13 (IL- 13) and vascular cell adhesionfactor- 1 (VCAM- 1) in the two groups were decreased when compared with those before treatment (P＜0.05)，and the serum levels of IL-4，IL-13 and VCAM-1 in the observation group were lower than those inthe control group (P＜0.05). Conclusion： The therapy of Yupingfeng Granules combined with sublingualdesensitization with Dermatophagoides Farinae Drops has a significant therapeutic effect on the treatmentof children allergic rhinitis with syndrome of lung- spleen qi deficiency， which is beneficial to theimprovement of the clinical symptoms and immune ability of the body as well as the decrease of theinflammatory reactions.