安宫牛黄丸治疗基底节区脑出血患者颅内高压疗效观察及对血清B 型钠尿肽水平的影响

目的：观察安宫牛黄丸治疗基底节区脑出血患者颅内高压疗效及对氧化应激指标以及血清B 型钠尿肽（BNP） 水平的影响。方法：选取80 例痰热内闭证基底结节区脑出血患者，按随机数字表法分为观察组及对照组各40 例，对照组接受脑出血颅内高压常规方案治疗，观察组在对照组基础上联合安宫牛黄丸治疗。比较2 组治疗前后颅内压（ICP）、平均动脉压（MAP）、心率（HR）、中医证候积分、总抗氧化能力（T-Aoc）、超氧化物歧化酶（SOD） 以及BNP 水平的变化。结果：治疗后，2 组ICP、MAP 水平均较治疗前下降（P＜0.05），HR 水平均较治疗前上升（P＜0.05）；观察组ICP、MAP 水平均低于对照组（P＜0.05），HR 水平高于对照组（P＜0.05）。治疗后，剧烈头痛、动作迟缓、嗜睡中医证候积分均较治疗前下降（P＜0.05），观察组上述3 项中医证候积分均低于对照组（P＜0.05）。治疗后，2 组T-Aoc、SOD 水平均较治疗前上升（P＜0.05），BNP水平均较治疗前下降（P＜0.05）；观察组T-Aoc、SOD 水平均高于对照组（P＜0.05），BNP 水平低于对照组（P＜0.05）。结论：安宫牛黄丸治疗痰热内闭证基底节区脑出血患者，能有效改善颅内高压，缓解氧化应激反应，促进心脏功能的恢复。

Observation on Curative Effect of Angong Niuhuang Pills on Intracranial Hypertensionin Patients with Cerebral Hemorrhage in Basal Ganglia and Its Effect on Serum BTypeNatriuretic Peptide Levels

Abstract： Objective： To observe the curative effect of Angong Niuhuang Pills on intracranialhypertension in patients with cerebral hemorrhage in basal ganglia and its effect on oxidative stress indexesand serum B-type natriuretic peptide (BNP) levels. Methods：A total of 80 cases of patients with cerebralhemorrhage in basal ganglia with phlegm-heat internal block syndrome were selected and divided into theobservation group and the control group according to the random number table method，with 40 cases ineach group. The control group was given routine treatment for intracranial hypertension of cerebralhemorrhage，and the observation group was additionally treated with Angong Niuhuang Pills based on thetreatment of the control group. The changes in intracranial pressure (ICP)，mean arterial pressure (MAP)，heart rate (HR)，traditional Chinese medicine (TCM) syndrome scores，total antioxidant capacity (T-Aoc)，superoxide dismutase (SOD) and BNP levels were compared before and after treatment between the two groups. Results： After treatment， the levels of ICP and MAP in the two groups were decreased whencompared with those before treatment (P＜0.05)， and HR levels were increased when compared withthose before treatment (P＜0.05)； the levels of ICP and MAP in the observation group were lower thanthose in the control group (P＜0.05)，and HR level was higher than that in the control group (P＜0.05). Aftertreatment， the scores of TCM syndromes including severe headache， slow movement and somnolencewere decreased when compared with those before treatment (P＜0.05)，and the above three scores in theobservation group were lower than those in the control group (P＜0.05). After treatment，the levels of TAocand SOD in the two groups were increased when compared with those before treatment (P＜0.05)，and BNP levels were decreased when compared with those before treatment (P＜0.05)；the levels of TAocand SOD in the observation group were higher than those in the control group (P＜0.05)，and BNP levelwas lower than that in the control group (P＜0.05). Conclusion： The additional application of AngongNiuhuang Pills for patients with cerebral hemorrhage in basal ganglia with phlegm- heat internal blocksyndrome can effectively improve intracranial hypertension，relieve oxidative stress reactions and promotethe recovery of heart function.