激光联合吡美莫司乳膏及他克莫司软膏治疗白癜风的临床效果

分析激光与吡美莫司乳膏及他克莫司软膏联合治疗白癜风的临床效果。方法 选取北京京城 皮肤医院皮肤科2022年6月-12月收治的82例白癜风患者为研究对象，采用随机数字表法分为常规组和联 合组，各41例。常规组予以激光治疗，联合组在激光治疗基础上应用吡美莫司乳膏及他克莫司软膏联合 治疗，比较两组临床疗效、免疫功能、症状改善情况及不良反应发生情况。结果 联合组治疗总有效率 为97.56%，高于常规组的82.93%，差异有统计学意义（P ＜0.05）；联合组治疗后IgA、IgM及IgG水平高 于常规组，差异有统计学意义（P ＜0.05）；联合组治疗后白斑数量少于常规组，白斑面积小于常规组， 差异有统计学意义（P ＜0.05）；联合组不良反应发生率为7.32%，低于常规组的29.27%，差异有统计学 意义（P＜0.05）。结论 激光与吡美莫司乳膏及他克莫司软膏联合治疗白癜风可提高治疗效果，提升机体 免疫功能，减少白斑个数和白斑面积，降低不良反应发生几率，值得临床应用。

Clinical Effect of Laser Combined with Pimecrolimus Cream and Tacrolimus Ointment in the Treatment of Vitiligo

To analyze the clinical effect of laser combined with pimecrolimus cream and tacrolimus ointment in the treatment of vitiligo. Methods A total of 82 patients with vitiligo admitted to the Department of Dermatology, Beijing Jingcheng Skin Hospital from June to December 2022 were selected as the research objects. They were divided into conventional group and combined group by random number table method, with 41 patients in each group. The conventional group was treated with laser therapy, and the combined group was treated with pimecrolimus cream and tacrolimus ointment on the basis of laser therapy. The clinical efficacy, immune function, symptom improvement and adverse reactions were compared between the two groups. Results The total effective rate of treatment in the combined group was 97.56%, which was higher than 82.93% in the conventional group, and the difference was statistically significant (P <0.05). After treatment, the levels of IgA, IgM and IgG in the combined group were higher than those in the conventional group, the differences were statistically significant (P <0.05). After treatment, the number of white spots in the combined group was less than that in the conventional group, and the area of white spots was less than that in the conventional group, the differences were statistically significant (P <0.05). The incidence of adverse reactions in the combined group was 7.32%, which was lower than 29.27% in the conventional group, the difference was statistically significant (P <0.05). Conclusion Laser combined with pimecrolimus cream and tacrolimus ointment can improve the therapeutic effect for vitiligo patients, improve their immune function, reduce the number and area of leukoplakia, and reduce the incidence of adverse reactions, which is worthy of clinical application.