| 鱼精蛋白个体化使用减少心脏直视手术后患者出血的研究 |
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| 引用本文： | 唐佳丽,李刚,杜磊,刘进. 鱼精蛋白个体化使用减少心脏直视手术后患者出血的研究[J]. 中国胸心血管外科临床杂志, 2010, 17(2) |
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| 作者姓名： | 唐佳丽 李刚 杜磊 刘进 |
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| 作者单位： | 四川大学华西医院,麻醉科,成都,610041 |
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| 基金项目： | 国家自然科学基金资助项目 |
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| 摘 要： | 目的比较个体化与按体重给予鱼精蛋白对体外循环(CPB)手术后患者出血和输血量的影响,以减少CPB后出血并发症的发生。方法40例拟在CPB下行择期心脏手术的成年患者随机分为两组,实验组:根据肝素-鱼精蛋白滴定法结果给予鱼精蛋白;对照组:术前给予肝素,按1∶1的比例给予鱼精蛋白。记录术后1 h、2 h和24 h的胸腔引流量和输血量。结果实验组鱼精蛋白用量明显大于对照组(P0.05),而胸腔引流量(出血量)于术后1 h(180±83 ml vs.285±156 ml,P=0.012)、2 h(74±31 ml vs.114±44 ml,P=0.002)、24 h(465±167 ml vs.645±207 ml,P=0.004)和红细胞悬液输入量(0.15±0.27 Uvs.0.80±0.96 U,P=0.018)均少于对照组。结论与目前临床上使用的根据CPB前肝素用量给予鱼精蛋白的方法比较,滴定法指导的个体化给予鱼精蛋白能减少CPB后患者的胸腔引流量(出血量)和红细胞输入量。
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| 关 键 词： | 鱼精蛋白 个体化 出血 体外循环 |
Individualized Protamine Reduces Postoperative Blood Loss after Open Heart Surgery Undergoing Cardiopulmonary Bypass |
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| TANG Jia-li,LI Gang,DU Lei,LIU Jin.. Individualized Protamine Reduces Postoperative Blood Loss after Open Heart Surgery Undergoing Cardiopulmonary Bypass[J]. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2010, 17(2) |
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| Authors: | TANG Jia-li LI Gang DU Lei LIU Jin. |
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| Affiliation: | TANG Jia-li,LI Gang,DU Lei,LIU Jin.(Department of Anesthesiology,West China Hospital,Sichuan University,Chengdu610041,P.R.China) |
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| Abstract: | Objective To compare individualized protamine with protamine based on weight in terms of postoperative bleeding and blood transfusion dose,in order to reduce postoperative bleeding complications.Methods Forty adult patients scheduled to elective open heart surgery under cardiopulmonary bypass(CPB) were randomly divided into two groups.For patients in the experimental group,we gave them protamine based on heparin-protamine titration result,while patients in the control group received the same amount of prota... |
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| Keywords: | Protamine Individualized protamine Blood loss Cardiopulmonary bypass |
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