| 5-HT6受体基因多态性与持续性躯体形式疼痛障碍的关联分析 |
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| 引用本文： | 骆艳丽,吴文源,江三多,张野,钱伊萍,汪栋祥. 5-HT6受体基因多态性与持续性躯体形式疼痛障碍的关联分析[J]. 中国民康医学, 2001, 13(6): 323-325 |
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| 作者姓名： | 骆艳丽 吴文源 江三多 张野 钱伊萍 汪栋祥 |
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| 作者单位： | 1. 200065,同济大学附属同济医院
2. 上海精神卫生中心 |
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| 摘 要： | 目的探讨中国汉族人群中5-羟色胺(5-HT6)受体基因C267T多态性与持续性躯体形式疼痛障碍的相互关系.方法应用聚合酶链式反应(PCR)-限制性片段长度多态性(RFLP)技术,在51例持续性躯体形式疼痛障碍患者和60例正常对照中观察了5-HT6受体基因多态性的分布.结果5-HT6受体基因的C/T基因型与持续性躯体形式疼痛障碍之间存在负关联(OR=0.43,Z=2.05,P<0.05).结论从整体看,5-HT6受体基因多态性与持续性躯体形式疼痛障碍的发生有关.
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| 关 键 词： | 疼痛 5-HT6受体 基因 多态性 关联 |
| 修稿时间： | 2001-06-08 |
The inter-relationship between 5-HT6 receptor Gene Polymorphism and persist somatoform pain disorder in Chinese |
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| LUO Yanli,WU Wenyuan,JIANG Sanduo et al.. The inter-relationship between 5-HT6 receptor Gene Polymorphism and persist somatoform pain disorder in Chinese[J]. medical journal of chinese peoples health, 2001, 13(6): 323-325 |
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| Authors: | LUO Yanli WU Wenyuan JIANG Sanduo et al. |
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| Abstract: | Objectives: To explore the inter-relationship between 5-HT6 receptor gene polymorphism and persist somatoform pain disorder in Chinese. Methods: The genetic polymorphism of 5-HT6 receptor gene was on 51 patients and 60 controls with PCR-RFLP methods. Then the association between 5-HT6 receptor gene polymorphism and patients was analyzed. Results: There was found to be negative relationship between the C/T genetype of the 5-HT5 releptor gene and somatoform pain inpa tients(OR=0.43,Z=2.05,P<0.05).Conclusion:In general,There is relationship betwe en receptor gene and somatoform pain disorder. |
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| Keywords: | Pain 5-HT6 receptor Gene Polymorphism relationship |
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