| 聚维酮在阿霉素诱导膀胱癌EJ细胞凋亡模型中的作用机制 |
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| 引用本文： | 杨军军,孔万仲,倪莉. 聚维酮在阿霉素诱导膀胱癌EJ细胞凋亡模型中的作用机制[J]. 中国卫生检验杂志, 2007, 17(1): 104-105 |
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| 作者姓名： | 杨军军 孔万仲 倪莉 |
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| 作者单位： | 温州医学院附二院血液室,浙江,温州,325027 |
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| 摘 要： | 目的:探讨聚维酮(PVP)在体外加阿霉素(ADM)后诱导EJ细胞发生凋亡的情况以及一些相关机制。方法:应用流式细胞仪(FCM)检测ADM诱导EJ细胞的凋亡率、PVP EJ细胞的凋亡率以及PVP ADM对EJ细胞的诱导凋亡率的情况。结果:PVP对ADM诱导膀胱癌EJ细胞凋亡无影响。结论:PVP在整个诱导过程中并没有协同作用,只起到粘附作用,使得药物停留在EJ细胞表面的作用时间延长,从而达到大量杀伤EJ细胞的作用。
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| 关 键 词： | 阿霉素 细胞凋亡 聚维酮 粘附 |
| 文章编号： | 1004-8685（2007）01-0104-02 |
| 收稿时间： | 2006-10-10 |
| 修稿时间： | 2006-10-10 |
Mechanism of PVP to apoptosis of EJ cells of bladder cancer resulted from ADM |
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| Yang Jun-jun,Kong Wan-zhong,Ni Li. Mechanism of PVP to apoptosis of EJ cells of bladder cancer resulted from ADM[J]. Chinses Journal of Health Laboratory Technology, 2007, 17(1): 104-105 |
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| Authors: | Yang Jun-jun Kong Wan-zhong Ni Li |
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| Affiliation: | The Hematology lab, Second Hospital Affiliated to Wenzhou Medical College, Wenzhou 325027, China |
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| Abstract: | Objective:To study the effect of PVP on EJ cell apoptosis resulted from ADM in vitro and the related mechanism.Methods:The apoptosis of EJ cells treated with ADM,those treated with PVP and those treated with ADM and PVP were detected by flow cytometry(FCM) respectively.Results:PVP had no influences on the apoptosis of EJ cells resulted from ADM.Conclusion:The effect of PVP on EJ cells apoptosis is not cooperated but conglutination.PVP could extend the time of ADM of resting on the surface of EJ cells and kill a great deal of EJ cells. |
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| Keywords: | ADM Cell apoptosis PVP Conglutination |
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