Bordetella pertussis adenylate cyclase-hemolysin induces interleukin-6 secretion by human tracheal epithelial cells |
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| Authors: | Bassinet Laurence Fitting Catherine Housset Bruno Cavaillon Jean-Marc Guiso Nicole |
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| Affiliation: | Unité Prévention et Thérapie Moléculaires des Maladies Humaines, Institut Pasteur, 25, rue du Dr. Roux, 75724 Paris Cedex 15, France. |
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| Abstract: | ![]()
After interaction with tracheal epithelial cells, Bordetella pertussis induces the secretion of interleukin-6. This secretion is dependent on the expression of adenylate cyclase-hemolysin by the bacterium but not on the expression of other characterized bacterial toxins or adhesins. This finding confirms the important role of adenylate cyclase-hemolysin in the pathogenicity of the bacterium. |
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