Prospective epidemiological study of invasiveHaemophilus influenzae disease in adults |
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| Authors: | F Deulofeu J M Nava F Bella C Martí M A Morera B Font D Fontanals J Lite J Garau A Calderón M T Coll S Uriz V Pineda |
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| Institution: | (1) Servicio de Medicina Interna, Hospital General de Granollers, 08400 Granollers, Barcelona, Spain;(2) Sección de Microbiología, Hospital General de Granollers, 08400 Granollers, Barcelona, Spain;(3) Servicio de Pediatría, Hospital General de Granollers, 08400 Granollers, Barcelona, Spain;(4) Servicio de Medicina Intensiva, Hospital Mútua de Terrassa, 08221 Terrassa, Barcelona, Spain;(5) Servicio de Microbiología, Hospital Mútua de Terrassa, 08221 Terrassa, Barcelona, Spain;(6) Departamento de Medicina Interna, Hospital Mútua de Terrassa, 08221 Terrassa, Barcelona, Spain;(7) Servicio de Medicina Interna, Hospital de Terrassa, 08227 Terrassa, Barcelona, Spain;(8) Sección de Microbiología, Hospital de Terrassa, 08227 Terrassa, Barcelona, Spain;(9) Servicio de Pediatriía, Hospital de Terrassa, 08227 Terrassa, Barcelona, Spain;(10) Servicio de Medicina Interna, Hospital de Sabadell, 08208 Sabadell, Barcelona, Spain;(11) Servicio de Microbiología, Hospital de Sabadell, 08208 Sabadell, Barcelona, Spain;(12) Servicio de Pediatría, Hospital de Sabadell, 08208 Sabadell, Barcelona, Spain;(13) Sección de Microbiología, Hospital de Mollet, 08100 Mollet Barcelona, Spain |
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| Abstract: | The incidence and characteristics of invasiveHaemophilus influenzae disease were studied in 43 adult patients admitted to the acute care hospitals in El Vallés County (Barcelona, Spain) between January 1987 and June 1992. The annual incidence ofHaemophilus influenzae disease was 1.2 per 100,000 inhabitants. Pneumonia occurred in 24 patients, meningitis in five, intraabdominal infections in three, obstetric infections in two, epiglottitis in two and cellulitis in one. In six patients the source of infection was unknown. Ten (23 %) of the infections were hospital acquired. Underlying conditions were diagnosed in 30 (70 %) patients. NontypeableHaemophilus influenzae strains predominated in all adult age groups. Sixty-one percent of type b and 34 % of nontypeable strains were ampicillin resistant (p=0.08). Multiple antibiotic resistance was also high among type b (53 %) and nontypeable (18 %) strains. The mortality rate was significantly higher in patients with pneumonia, bactaeremia from an unidentified focus or shock at presentation. |
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