血清胱抑素C测定对系统性红斑狼疮肾损害早期诊断的价值

目的探讨血清胱抑素C(CysC)对系统性红斑狼疮肾损害早期诊断的价值。方法系统性红斑狼疮患者45例,健康对照组20例,采集空腹静脉血3mL,留取中段尿约20mL,同时检测血清尿素(UREA)、尿酸(UAC)、肌酐(CREA)、尿微量清蛋白(UALB)、尿乙酰氨基葡萄糖苷酶(NAG)含量,组间均数采用t检验,以P<0.05为差异有统计学意义。结果系统性红斑狼疮尿蛋白阴性组血清CysC浓度较健康对照组明显升高,其他检测项目均在正常值范围内;尿蛋白阳性组与尿蛋白阴性组比较,血清CysC水平与UREA、UAC、CREA、UALB、NAG有良好的相关性,呈正相关。结论血清CysC是理想的系统性红斑狼疮肾功能早期损害的实验室指标,为临床狼疮肾炎进行早期干预治疗及改善狼疮患者预后提供主要依据。

The value of the serum cystatin C measured on the diagnosis of renal damage in early systemic lupus erythematosus

Objective To investigate the value of serum cystatin C （CysC） for early diagnosis of kidney damage in systemic lupus erythematosus. Methods 45 patients of systemic lupus erythematosus and 20 healthy person of control group were collected with fasting blood 3 mL, urine specimens approximately 20 mL, while serum urea （UREA） ,uric acid （UAC）, creatinine （CREA）, urinary microalbuminuria protein （UALB）, and urinary acetyl glucosaminidase （NAG） levels were determined. T test was used in the number of groups with the result of P~0.05, which means that it was statistically significant different. Results Serum CysC levels in the urine protein negative of systemic lupus erythematosus group was significantly higher than that in the control group,and the other test items were within normal range. There was a good correlation and positive correlation in the serum CysC levels, UREA, UAC,CREA,UALB and NAG between the urine protein positive and negative group. Conclusion The serum CysC is an ideal of early damage of systemic lupus erythematosus renal laboratory indicators for early intervention of clinical treatment of lupus nephritis,lupus patients to improve the prognosis of the main basis.