肿瘤患者贫血的相关指标分析

目的分析703例各种肿瘤患者贫血的发生率和相关实验室指标,探求肿瘤性贫血的一般规律,为临床应对肿瘤贫血症状提供实验室依据。方法回顾性分析703例肿瘤患者,包括消化道、呼吸、生殖、淋巴瘤等贫血发生率;血清铁及转铁蛋白采用日立7080全自动生化仪。红细胞及参数采用Sysmex 1800I血细胞分析仪。结果 703例肿瘤患者血红蛋白水平低于120g/L的占76.7%,多数处于90～120g/L,贫血程度和病程与临床分期有关,与肿瘤类型、性别、年龄相关性较小（r〈0.40）。铁代谢异常的患者占46.13%。结合红细胞参数和血清铁、转铁蛋白,56%患者为小细胞低色素贫血伴随血清铁水平降低,35%患者贫血不伴有血清铁水平下降。结论肿瘤患者伴随贫血的发生率高。贫血症状一半以上为小细胞低色素性贫血,同时血清铁水平降低;但部分患者不伴血清铁水平低下,提示补铁需谨慎。

Analysis on relative indexes of anemia in tumor patients

Objective To analyze the incidence of anemia among 703 cases of various tumors and the related laboratory indexes to investigate the general rules of tumoral anemia and provide the laboratory basis for coping with tumoral anemia in clinic.Methods 703 cases of tumors including digestive tract,respiratory,reproductive systems and lymphoma were retrospectively analyzed on the incidence of anemia.Serum iron（SI） and transferrin（TF） were tested by Hitachi 7080 full automatic biochemical analyzer and parameters of red blood cell were detected by Sysmex 1800i automatic blood cell analyzer.Results Among 703 cases,hemoglobin level below 120 g/L accounted for 76.7%,most cases were 90-120 g/L.The degree of anemia was related with the disease course ated clinical stages and less correlated with tumor type,sex and age.（r0.40）.The patients with abnormal iron metabolism accounted for 56%.Combined with the RBC parameters,SI and TF,56% of cases were microcytichypochromicanemia with low SI,and 35% of the cases without low SI.Conclusion The incidence rate of accompanying anemia in the tumor patients is high,which reminds doctors should actively conduct the antianemic treatment.More than half of anemic symptoms are microcytichypochromicanemia with low SI.But partial patients are not accompanied with low SI,which suggests that iron supplement should be careful.