泌尿生殖道支原体感染状况及药敏分析

目的了解东莞市石龙地区支原体感染的状况及药敏情况,为临床合理用药提供参考依据。方法采用珠海益民生物工程制品厂提供的支原体培养、鉴定、药敏检测试剂盒进行试验。结果 1 730例标本中共检出支原体840例,总检出率为48.6%,其中解脲脲原体（Uu）741例,检出率为42.8%;解脲脲原体合并人型支原体（Uu＋Mh）89例,检出率为5.1%;人型支原体（Mh）10例,检出率为0.6%。男性检出率为20.5%,女性检出率为51.4%,女性明显高于男性。药敏结果表明,单纯Uu感染的患者交沙霉素、强力霉素、克拉霉素敏感率较高,均在90%以上;单纯Mh感染的患者交沙霉素和强力霉素敏感率均为80%;而Uu、Mh合并感染的患者交沙霉素和强力霉素相对较敏感,均在75%以上。结论石龙地区支原体感染以Uu感染为主,交沙霉素、强力霉素和克拉霉素可作为本地区支原感染的经验性用药,但临床治疗前应尽可能进行支原体培养及药敏试验,合理规范用药。

Mycoplasma infection status in urogenital tract and drug susceptibility analysis

Objective To understand the status of mycoplasma infection and drug susceptibility in the Shilong region and to provide reference basis for clinical rational drug use.Methods The reagents kits produced by Zhuhai Yimin bioengineering enterprise were adopted to perform mycoplasma culture,identification and susceptibility testing.Results Among 1 730 specimens,840 cases of mycoplasma infection were detected with the total detection rate of 48.6%,including Ureaplasma urealyticum（Uu） infection in 741 cases（42.8%）,Mycoplasma hominis（Mh） infection in 10 cases（0.6%） and Uu＋Mh infection in 89 cases（5.1%）.The detection rate was 20.5% in males and 51.4% in females,females′ were obviously higher than males′.The results of dug susceptibility tests showed that simple Uu infection had higher sensitivity（90%） to josamycin,doxycycline and clarithromycin,simple Mh infection had the sensitivity（80%） to josamycin and doxycycline,and Uu＋Mh infection were relatively sensitive to josamycin and doxycycline（ 75%）.Conclusion Mycoplasma infection in Shilong region is dominated by Uu infection.Josamycin,doxycycline and clarithromycin can be used as empirical medication to treat mycoplasma infections in theis region.But before clinical treatment,the mycoplasma culture and drug susceptibility tests should be performed as possible for rational and standardized medication.