The concentrations of xanthine and hypoxanthine in cerebrospinal fluid as therapeutic guides in hydrocephalus

Xanthine, hypoxanthine, and total oxypurine levels were determined in the cerebrospinal fluid of 18 hydrocephalic patients and 8 healthy controls by high-performance liquid chromatography (HPLC). Eight of the hydrocephalic patients were self-compensated and 10 had shunts implanted during the course of the study. The mean xanthine, hypoxanthine, and total oxypurine levels in the normal children were 5.20, 5.94 and 11.29 mol/l, respectively. In self-compensated hydrocephalics these levels were respectively 6.06, 6.50 and 12.57 mol/l. In noncompensated hydrocephalics, they were 11.40, 10.79 and 22.19 mol/l. The differences between the latter group and the first two are statistically significant (P<0.001). Fifteen days after implantation of shunts in the noncompensated hydrocephalics, the mean xanthine levels had fallen to 4.61 mol/l, the mean hypoxanthine levels to 5.03 mol/l, and the mean total oxypurine levels to 9.64 mol/l. The change is statistically significant (P<0.001). In light of these findings we propose that xanthine, hypoxanthine, and total oxypurine levels be used in cases of hydrocephalus as guides for therapeutic action and to monitor progress.