肾性贫血中未成熟网织红细胞的变化及意义

目的:探讨未成熟网织红细胞指数(IRF)在肾性贫血中的变化及意义。方法:采用Beckman-CoulterGen.S自动血细胞分析仪,检测135例慢性肾功能不全患者不同病期(包括肾功能不全代偿期41例、肾功能不全失代偿期45例、肾功能衰竭期49例)和50例正常对照组的IRF、网织红细胞百分比(Ret%)、红细胞(RBC)计数和血红蛋白(Hb)含量,同时检测其血清肌酐(Cr)和尿素氮(BUN)含量,并与50例正常对照组进行比较分析。结果:IRF在肾功能不全代偿期组显著低于对照组(P<0.05),而肾功能不全失代偿期组和肾功能衰竭期组均显著高于对照组(分别P<0.05和P<0.01)。Ret%在肾功能不全失代偿期组和肾功能衰竭期组显著高于对照组(分别P<0.05和P<0.01)。RBC、Hb水平均随着Cr和BUN水平的升高而显著减低,互相间有较好的相关性(分别为r=-0.604和-0.627;r=-0.600和-0.628,P<0.01),而IRF、Ret%与Cr、BUN的变化无明显相关性。结论:IRF及其相关参数的检测,有助于了解肾病患者的骨髓增生程度和红系的生长情况。IRF在肾病早期时降低,肾病末期由于EPO...

The changes of immature reticulocyte fraction in renal anemia and its significance

Objective To explore the changes of immature reticulocyte fraction (IRF) in renal anemia. Methods One-hundred and thirty five patients with chronic renal insufficiency(CRI) at different stages(include CRI patients during compensative stage and decompensative stage and chronic renal failure stage)and 50 healthy people were studied. The IRF, percent of reticulocyte(Ret%), red blood cell(RBC) and hemoglobin (Hb) were determined with Beckman-Coulter Gens. Auto Hematology Analyzer. The creatinin(Cr) and urea nitrogen(BUN) were determined with Hitachi 7600 Analyzer. The results were analyzed and compared between the different stages of CRI and the normal controls. Results IRF in CRI patients during compensative stage was significant lower than that in normal controls (P< 0.05). IRF and Ret%in CRI patients during decompensative stage and chronic renal failure stage were significant higher than that in normal controls (both P< 0.05 and P< 0.01, respectively). Following increase levels of BUN and Cr, RBC and Hb from compensative stage to failure stage gradually decreased. The negative correlations were found between RBC or Hb and Cr or BUN (r=-0.604 and -0.627;r=-0.600 and-0.628,respectively). During the development of CRI, IRF and Ret%had no correlations with Cr and BUN. Conclusions The results indicated that the changes of IRF in renal anemia could reflect erythropoiesis. IRF decrease in early renal disease, while increased in end-stage renal disease. The changes of IRF were of value in reflecting the effect of therapy using EPO.