孕妇主、被动联合免疫阻断乙肝母婴传播的研究

目的:探讨乙型肝炎母婴垂直传播阻断的影响因素和免疫效果。方法:51例HBV感染但无临床症状的孕妇分成三组,试验组Ⅰ:孕妇为HBAg单阳性,产期及新生儿均注射过HBIG;试验组Ⅱ:孕妇为HBsAg、HBeAg双阳性,产前及新生儿均注射过HBIG;对照组;孕妇为HBsAg单阳性或HBsAg、HBeAg双阳性,产前及新生儿均未注射过HBIG;上述所有新生儿均注射过乙肝疫苗。随访三年,每年检测新生儿HBeAg和抗---HBs。结果:实验组(Ⅰ+Ⅱ)总的HBsAg携带率从5.00%降为2.50%,对照组的HBsAg携带率为0%。对照组抗-HBs阳性率、滴度下降更明显(p<0.05)。结论:联合免疫以及单纯乙肝疫苗免疫对阻断乙肝母婴传播的效果都是确定的,联合免疫对维持乙肝疫苗持久效果更佳,应重视对乙肝高危新生儿的监测和随访。

Study of preventing HBV Mother-to-infant by Aetive and passive Immunization of pregnant Women

Objective: To study the factors which can influence the interruption of maternalfetal transmission of hepatitis B virus(HBV)and the effects of cambined immunization. Methods: 51 partuients with hepatitis B(liver function was normal)were randomly assigned to three groups .Women with positive serum hepatitis B surface antigen(HBsAg) in HBIG group receved 200 IU of HBIG in intramuscularly at7、8、9months of pregnancy.The newborns received 200 IU of HBIG in intramuscularly within 24 hours and 15day after birth.Women with positive serum hepatitis B surface antigen(HBsAg)and positive HBeAg in HBIG group received 200 IUof HBIG intramuscularly at7、8、9months ofpregnancy.The newborns received 2001IU of HBIG in intramuscularly within 24hours and 15days after birth.Women with positive serum hepatitis Bsurface antigen(HBsAg)orpositive HBeAg in control group were not given HBIG.All newborns of three groups were immunized with threedoses of hepatitis B vaccine. All of them were followed up for three years, the Serum HBsAg positive rate and anti-HBs of all newborns were tested every year……Results Serum HBsAg positive rate of infants in HBIG I griup were decreased from 5.00%to2.50%.SerumHBsAg positive rate of infants in control group were 0.00%.the positive rate of anti-HBs in controi group was significantiy lower than other groups.(p<0.05).Conclusions: The HBV Mother-infant transmission can be decreased by canbined immunization and hepatitis B vaccine. The long-term efficacy of HBvaccination in dangerous newborn should be deeply study