Predictive value of argyrophilic nucleolar-organizer-region-associated proteins in bladder cancer, using cell-imprint preparations |
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Authors: | Mitsunobu Masuda Yasuo Takano Masayuki Iki Shin-ichirou Jinza Sumio Noguchi Yoshinobu Kubota Masahiko Hosaka |
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Affiliation: | (1) Department of Urology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, 236 Yokohama-shi, Kanagawa-ken, Japan;(2) Department of Pathology, Kitasato University School of Medicine, 1-15-1 Kitasato, 228 Sagamihara-shi, Kanagawa-ken, Japan;(3) Department of Environmental Health, Fukui Medical School, 23 Shimoaizuki, Matsuoka-chou, Yoshida-ku, 91011 Yoshida-gun, Fukui-ken, Japan |
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Abstract: | The predictive value of quantifying argyrophilic nucleolar-organizer-region-associated proteins (Ag-NOR) in routinely processed paraffin-embedded tissue sections of bladder cancer remains controversial. The purpose of this study was to determine whether cell-imprint preparations facilitate a more accurate determination of the mean number of Ag-NOR per cell (Ag-NOR score). The utility of using the Ag-NOR scores of cell-imprint preparations as a prognostic indicator in patients with bladder cancer was explored. We evaluated 90 patients with newly diagnosed bladder cancer using cell-imprint preparations to determine Ag-NOR score. The score significantly correlated with known prognostic factors associated with this tumor, including histological grade (P<0.001), pathological stage (P<0.01), and papillary structure (P<0.001). Furthermore, the Ag-NOR score appeared to be an independent predictor of intravesical tumor recurrence of superficial bladder cancer (P<0.05). These results suggest that the Ag-NOR score determined in a cell imprint preparation may serve as a useful prognostic indicator in bladder cancer.Abbreviation Ag-NOR argyrophilic nucleolar-organizer-region-associated proteins |
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Keywords: | Nucleolar organizer region Bladder neoplasm Imprint cytology Transitional cell carcinoma Prognosis |
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