Formation of DNA adduct 8-hydroxy-2'-deoxyguanosine induced by man-made mineral fibres |
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| Authors: | P Leanderson P S?derkvist C Tagesson O Axelson |
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| Affiliation: | Department of Occupational Medicine, Faculty of Health Sciences, Link?ping, Sweden. |
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| Abstract: | Two man-made mineral fibres, rockwool and glasswool, were found to mediate hydroxylation of deoxyguanosine and calf thymus DNA to form the DNA adduct 8-hydroxy-2'-deoxyguanosine. The modification of the nucleoside is probably mediated by hydroxyl radicals and may play a role in fibre-induced carcinogenesis. |
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