2型糖尿病并缺血性脑血管疾病患者脑动脉狭窄的影像学研究

目的:利用全脑数字减影血管造影(DSA)观察2型糖尿病(病程≤5年)并缺血性脑血管疾病患者脑动脉狭窄的特点,为糖尿病并缺血性脑血管疾病的二级预防提供科学依据。方法:258例缺血性脑血管疾病患者接受计算机断层血管造影(CTA)检查,根据WHO1999年糖尿病诊断标准,分为糖尿病组(DM组)和非糖尿病组(NDM组),观察两组动脉狭窄发生率、动脉狭窄病变分布及动脉狭窄程度等内容。结果:DM组动脉狭窄发生率为76.71%,而NDM组动脉狭窄发生率为58.82%,差异显著。两组动脉病变均以多支狭窄为主,DM组多支动脉狭窄率占79.25%,而NDM组占49.00%,差异显著。两组动脉狭窄程度差异不显著。结论:糖尿病患者更易发生脑动脉狭窄,且狭窄范围更广泛、多发。病程5年之内的糖尿病并缺血性脑血管疾病动脉狭窄程度以中度狭窄为主。

Imaging characteristics of cerebral arteries stenosis in type 2 diabetes mellitus patients with ischemic cerebrovascular disease

Objective：To compare the characteristics of cerebral vessels stenosis in type 2 diabetes mellitus patients with ischemie cerehrovascular diseases （disease course ≤ 5 years） by computed tomographic angiography （CTA） or digital subtraction angiography （DSA）. Methods： According to the criteria set by WHO in 1999, 258 ischemic cerebrovascular disease patients diagnosed by CTA on cerebral veins were divided into two groups： diabetes mellitus （DM） group and non - diabetes mellitus （NDM） group. The characteristics of cerebral vessels lesions were compared between the two groups. Results： The rates of cerebrovascular stenosis in DM group and NDM group were 76.71% and 58.82% respectively （P 〈 0.01 ）. The incidence rates of multiple arteries stenosis in DM group and NDM group were 79.25% and 49.00% respectively （P 〈 0.01 ）. The difference of arteriostenosis degree was not observed between the two groups. Conclusion： The ischemic cerebrovaseular disease patients might be susceptible to arterial stenosis and more extensively involved arteries can be found in these patients with type 2 diabetes mellitus. Moderate arterial stenosis is common in DM patients with ischemic cerebrovascular disease.