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Regions of recognition by blocking antibodies on the light chain of botulinum neurotoxin A: antigenic structure of the entire toxin |
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| Authors: | Dolimbek Behzod Z Steward Lance E Aoki K Roger Atassi M Zouhair |
| Affiliation: | a Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA b Allergan, Inc., 2525 DuPont Drive, Irvine, CA 92612, USA |
| Abstract: | |
| Keywords: | Ab, antibody BoNT/A, botulinum neurotoxin serotype A BSA, bovine serum albumin H chain, the heavy chain (residues 449-1296) of BoNT/A HC, the C-terminal domain of the H chain (residues 855-1296) HN, the N-terminal domain of the H chain (residues 449-859) L chain, the light chain (residues 1-453) of BoNT/A (peptide numbers preceded by C indicate C-terminal domain peptides of the H chain, peptides denoted by N indicate N-terminal domain peptides of the H chain) MPA, mouse protection assay PBS, 0.15 M NaCl in 0.01 M sodium phosphate buffer, pH 7.20 |
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