| Institution: | Zhou,B.,Yang,L.,Sun,Q.M.,Cong,R.H.,Gu,H.J.,Tang,N.P.,Zhu,H.J.,Wang,B.Nanjing Med Univ,Dept Pharmacol,Key Lab Reproduct Med,Nanjing 210029,Jiangsu,Peoples R China.Nanjing Med Univ,Affiliated Hosp 1,Dept Gen Surg,Nanjing 210029,Jiangsu,Peoples R China.Nanjing Univ,Sch Med,Affiliated Drum Tower Hosp,Nanjing 210008,Jiangsu,Peoples R China. |
| Abstract: | OBJECTIVE:Epidemiologic findings are inconsistent concerning the association of endometrial cancer risk with cigarette smoking.We conducted a meta-analysis of epidemiologic studies to examine this relation.METHODS:A systematic literature search up to June of 2007 was performed in MEDLINE and EMBASE.Study-specific risk estimates were pooled using a random-effects model.RESULTS:Ten prospective and 24 case-control studies were included in the analysis of the effect of ever smoking.Ever smoking was statistically significantly associated with a reduced risk of endometrial cancer among prospective studies(relative risk 0.81;95% confidence intervalCI],0.74-0.88) and case-control studies(odds ratio 0.72;95% CI,0.66-0.79).The inverse association was significant among current and former smokers.Six prospective and 6 case-control studies were included in the quantitative analysis.We noted that an increase in smoking of 20 cigarettes per day was statistically significantly associated with 16% and 27% reduced risks of endometrial cancer in prospective and case-control studies,respectively.We also found that cigarette smoking was significantly associated with a decreased risk of endometrial cancer among postmenopausal women(relative risk 0.71;95% CI,0.65-0.78) but not among premenopausal women.In addition,the risk reduction seemed to be stronger among hormone replacement therapy users than nonusers.CONCLUSION:Cigarette smoking was found to be significantly associated with a reduced risk of endometrial cancer,especially among postmenopausal women.(C) 2008 Elsevier Inc.All rights reserved. |
