脑梗塞患者血清一氧化氮的浓度变化

目的 观察脑梗塞患者血清一氧化氮(NO)在发病不同时期的浓度变化,并对其临床意义进行了探讨。方法采用比色法对32例脑梗塞患者血清NO的浓度进行了测定。结果 同正常对照组比较,NO的浓度自发病7小时后明显增高,24小时后达到高峰,3天、5天后有所下降,7天后基本降至正常。脑梗塞组发病24小时后血清NO浓度与神经功能评分显著相关(r=0.06,P<0.01),而与梗塞灶直径不相关(P>0.05)。结论 血清NO在脑梗塞早期异常增高,提示其在发病过程中发挥了复杂而重要的作用,可表现为神经保护作用和神经破坏作用的双重机制。

The Change of Concerntration of Serum Nitric Oxide in the Patients With Cerebral Infarction

Objective In order to find out the certain interrelationship between the nitric oxide (NO) and cerebral infarction. The cincerntration of serum NO was measured in the different stages after the onset and explored clinically. Methods The colorimetry was adopted to detect the concerntration of serum NO in 32 patients with cerebral infarction in the acute period. Results Compared with that of the normal control,it began to elevate obviously after 7 hours of the onset,reached the peak 24 hours later, decreased after the 3 days later,and nearly returned to the normal 7 days later. The NO concerntration was significantly correlated with the nerve function rank(r = 0. 06,P<0. 05),in stead of lesions diameters. Conclusion The abnormal elevation of the serum NO concerntration at the early time of the onset indicated that NO might play a complex and important role in the process of the cerebral infarction, including both the neuroprotective and neurodestructive mechanism.