| 胰岛素对高血压大鼠脑缺血再灌注期脑梗死体积的影响 |
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| 引用本文： | 苏庆杰,黄海威,李玲,黄如训.胰岛素对高血压大鼠脑缺血再灌注期脑梗死体积的影响[J].海南医学院学报,2004,10(4):212-213,214. |
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| 作者姓名： | 苏庆杰 黄海威 李玲 黄如训 |
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| 作者单位： | 1. 海南医学院附属医院神经内科,海口,570102
2. 中山大学第一医院神经科,广州,510080 |
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| 基金项目： | 美国中华医学基金会(CMB)资助(NO:93-594) |
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| 摘 要： | 目的:观察胰岛素对脑缺血再灌注损伤的治疗作用。方法:制备肾血管性高血压大鼠(RHR),用线栓法复制大脑中动脉阻塞(MCAO),造成缺血6h再灌注18h,术后立即及6h后即时使用胰岛素,测定脑梗死体积的变化。结果:与对照组比较,实验组脑梗死体积及其占全大脑体积百分比、两半球体积差值均显著减小(P<0.05)。结论:胰岛素能减轻脑缺血再灌注损伤,早期用药效果更好。
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| 关 键 词： | 胰岛素 高血压 脑缺血 再灌注损伤 大鼠 Sprague-Dawley |
| 文章编号： | 1007-1237(2004)04-0212-02 |
THE EFFECT OF INSULIN ON CEREBRAL INFART AFTER REPERFUSION IN HYPERTENSION RAT |
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| SU Qing-jie,HUANG Hai-wei,LI Ling,et al..THE EFFECT OF INSULIN ON CEREBRAL INFART AFTER REPERFUSION IN HYPERTENSION RAT[J].Journal of Hainan Medical College,2004,10(4):212-213,214. |
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| Authors: | SU Qing-jie HUANG Hai-wei LI Ling |
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| Abstract: | Objective: To study the effect of insulin on reperfusion injur y after cerebral ischemia. Methods: The renovascular hypertension rats (RHR) with MCAO as described by Zea Longa for 6 hours and reperfusion for 18 hours .The infarct volume and the margine of the both hem isphere were measured at 24 hours after MCAO following treated immediately and 6 hours with insulin after reperfusion. Results: The infarct volume and the margine of the both hemisphere were significantly lower in the test groups compared with the controlled groups (P < 0.05). Conclusion: Insulin may reduce reperfusi on injury used as early as possible. |
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| Keywords: | Insulin Hypertension Ischemia Reperfusion injury RAT Sprague-Dawl ey |
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