Diagnosis of human immunodeficiency virus type 1 infection with different subtypes using rapid tests |
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Authors: | Phillips S Granade T C Pau C P Candal D Hu D J Parekh B S |
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Institution: | HIV Immunology and Diagnostics Branch, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA. |
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Abstract: | We evaluated six rapid tests for their sensitivity and specificity in diagnosing human immunodeficiency virus type 1 (HIV-1) infection using 241 specimens (172 HIV-1 positive, 69 HIV-1 negative) representing different HIV-1 subtypes (A n = 40], B n = 47], C n = 28], E n = 42], and F n = 7]). HIVCHEK, Multispot, RTD and SeroStrip were 100% sensitive and specific. Capillus failed to identify two of eight subtype C specimens (overall sensitivity of 98. 85%), while the SUDS test (the only test approved by the Food and Drug Administration) gave false-positive results for 5 of 69 seronegative specimens (specificity of 93.24%). Our results suggest that although rapid tests perform well in general, it may be prudent to evaluate a rapid test for sensitivity and specificity in a local population prior to its widespread use. |
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