小儿肾小球疾病血清α_1微球蛋白的变化

目的：探讨除血Ｃｒ、Ｃｃｒ之外反映肾小球功能的临床简便易行的检验方法。方法：用ＲＩＡ方法检测了一组原发性肾小球疾病患者急性期、恢复期的α１－Ｍ值。结果：急性期α１－Ｍ值明显高于恢复期，有统计学意义，随病情好转，血α１－Ｍ亦下降。结论：血清α１－Ｍ可以作为观察原发性肾小球疾病病情变化的指标，α１－Ｍ升高，示病情加重，小球功能损害明显，反之，示病情好转，小球功能得到恢复

Change in serum α 1-Microglobulin of Children with Glomerulopathy

Objective:To seek a clinically simple and easy test emthod for the reflection of glomerular function except for Cr and Ccr.Methods:The α 1-microglobulin (α 1-M) for the acute or recovery stage was determined by means of RIA in children with glomerular disease.Results:The α 1-M value at the acute stage was significantly higher than the value in the recovery period, suggesting that it was of statistical implication.Conclusion:The serum α 1-M can be used as a target for the observation of changes in the severity of primary glomerular diseases.Arise in the α 1-M value suggests a worse tendency of the disease and a glomerular function injury. Conversely, a decrease in the value represents an improvement and a function recovery.