血管生成拟态研究进展

血管生成拟态(VM)是近年来发现的一种与经典的肿瘤血管生成途径完全不同、不依赖机体内皮细胞的全新肿瘤微循环模式.它描述了在高度侵袭性肿瘤组织中通过肿瘤细胞的自身变形和基质重塑形成类似血管样的通道,通过这种结构有利于肿瘤组织获取营养、侵袭和转移.血管生成拟态的提出为肿瘤研究和治疗提供了新思路.

Research advances on vasculogenic mimicry

Vasculogenic mimicry is a kind of new pattern of tremor microcirculation found in resent years,which is totally different from the classic tumor angiogenesis and independent of vascular endothelial cells, It demonstrates that in highly-invasive tumor tissues vessel-like access can be formed by tumor cells, own deformation and matrix remodeling, which is conducive to tumor tissue for obtaining nutrition, invasion and me-tastasis. The statement of vasculogenic mimicry provides new ideas and new targets for the research and treat-ment of tumors.