Simultaneous expression of lymphoid and myeloid phenotypes in acute leukemia arising from myelodysplastic syndrome |
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Authors: | N Komatsu M Yoshida M Eguchi M Akashi R Sasaki S Sakamoto Y Miura |
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Institution: | Department of Medicine, Jichi Medical School, Tochigi-ken, Japan. |
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Abstract: | A 57-year-old female developed myelodysplastic syndrome (MDS) that terminated as a biphenotypic leukemia after exposure to chemoradiotherapy. Double staining of blast cells, using monoclonal antibodies specific for myeloid and lymphoid lineage, demonstrated that one-third of the leukemic cells simultaneously expressed the E rosette-associated antigen (OKT11) and myeloid-associated antigen (MY7). This finding suggests the possibility that some cases of MDS are clonal disorders that arise in a pluripotent stem cell that can also differentiate to T cell lineage. |
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Keywords: | myelodysplastic syndrome biphenotypic leukemia T cell lineage |
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