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Simultaneous genetic analysis of longitudinal means and covariance structure in the simplex model using twin data |
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| Authors: | Conor V. Dolan Peter C. M. Molenaar Dorret I. Boomsma |
| Affiliation: | (1) Department of Psychology, University of Amsterdam, Roetersstraat 15, 1018 WB Amsterdam, The Netherlands;(2) Department of Experimental Psychology, Free University, De Boelelaan 1115, 1081 HV Amsterdam, The Netherlands |
| Abstract: | A longitudinal model based on the simplex model is presented to analyze simultaneously means and covariance structure using univariate longitudinal twin data. The objective of the model is to decompose the mean trend into components which can be attributed to those genetic and environmental factors which give rise to phenotypic individual differences and a component of unknown constitution which does not involve individual differences. Illustrations are given using simulated data and repeatedly measured weight obtained in a sample of 82 female twin pairs on six occasions. |
| Keywords: | repeated measures genetic and environmental covariance structure mean trend lingitudinal twin data genetic simplex mode LISREL |
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