DNA异常甲基化与胃癌 |
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引用本文: | 郭维,魏品康.DNA异常甲基化与胃癌[J].广东医学,2011,32(21):2863-2866. |
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作者姓名: | 郭维 魏品康 |
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作者单位: | 1. 宁夏医科大学中医学院内科教研室,银川,750004 2. 第二军医大学附属长征医院中医科,上海,200003 |
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基金项目: | 宁夏自然科学基金资助项目 |
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摘 要: | 摘要:胃癌发生的分子机制中,遗传和表观遗传机制均起着重要的作用。DNA甲基化是研究最多的一种表观遗传学表达机制。DNA异常甲基化在胃癌发生发展中有重要作用,可以影响基因转录活性而不涉及DNA序列的改变。目前,胃癌相关基因异常甲基化已成为胃癌发病机制研究中的热点。本文就基因异常甲基化与胃癌的关系作一综述
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The relationship between gastric cancer and DNA methylation |
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Abstract: | ABSTRACT:
Both genetics and epigenetics play an important role in the development of gastric cancer. Among all the epigenetic mechanisms DNA methylation is a form whitch has been studied by many institutes.DNA methylation can contribute to the development of gastric cancer and is a hot topic in the tumor research. This aticle reviews the relaitionship between DNA methylation and gastric cancer. |
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