|
|||||
|
|
| 离子敏感型吲哚美辛眼用原位凝胶的制备与质量控制 | |
| 引用本文： | 郭丰广,郝吉福,孝建华,王建筑,李菲,姚欣. 离子敏感型吲哚美辛眼用原位凝胶的制备与质量控制[J]. 医药导报, 2011, 30(11): 1495-1498. DOI: 10.3870/yydb.2011.11.035 |
| 作者姓名： | 郭丰广 郝吉福 孝建华 王建筑 李菲 姚欣 |
| 作者单位： | 1. 泰山医学院药学院,山东泰安,271016;泰山医学院附属医院药剂科,山东泰安,271000 2. 泰山医学院药学院,山东泰安,271016 3. 泰山医学院附属医院药剂科,山东泰安,271000 4. 泰山医学院药学院2010届毕业班,山东泰安,271016 |
| 摘 要： | 目的以海藻酸钠为凝胶基质，羟丙基甲基纤维素（hydroxypropyl methyl cellulose，HPMC）为增黏剂，制备吲哚美辛离子敏感型眼用原位凝胶，并进行质量标准研究及释放度测定。方法通过对海藻酸钠与HPMC的配比研究，筛选最佳凝胶基质，制备吲哚美辛离子敏感型眼用原位凝胶；采用紫外分光光度法测定含量，用透析袋法进行体外释药实验，研究体外释药特性与机制。结果与吲哚美辛溶液相比，吲哚美辛离子敏感型眼用原位凝胶释药时间延长至8 h， 释药量均＞93%，而且具有良好的缓释效果。结论以海藻酸钠与HPMC制备的吲哚美辛离子敏感型眼用原位凝胶质量稳定，对眼部无刺激，且具有缓释、长效作用。 |
| 关 键 词： | 吲哚美辛；海藻酸钠；原位凝胶 离子敏感型 眼用；质量控制 |
Preparation and Quality Control of Ion-sensitive in Situ Gel of Indometacin for Eye Use |
|
| GUO Feng-guang,HAO Ji-fu,XIAO Jian-hua,WANG Jian-zhu,LI Fei,YAO Xin. Preparation and Quality Control of Ion-sensitive in Situ Gel of Indometacin for Eye Use[J]. Herald of Medicine, 2011, 30(11): 1495-1498. DOI: 10.3870/yydb.2011.11.035 | |
| Authors: | GUO Feng-guang HAO Ji-fu XIAO Jian-hua WANG Jian-zhu LI Fei YAO Xin |
| Affiliation: | GUO Feng-guang1,2,HAO Ji-fu1,XIAO Jian-hua2,WANG Jian-zhu1,LI Fei1,YAO Xin3(1.School of Pharmacy,Taishan Medical College,Taian 271016,China,2.Department of Pharmacy,Affiliated Hospital of Taishan Medical College,Taian 271000,3.Grade of Graduate,Class 2010,China) |
| Abstract: | Objective To study the preparation of ion-sensitive in situ gel of indomethacin for eye use by using sodium alginate as matrix and hydroxypropyl methyl cellulose(HPMC)as thickener,and investigate the quality standard and in vitro release of indomethacin gel. Methods To prepare ion-sensitive in situ gel of indomethacin for eye use and screen the best matrix of gel by comparing ratios of sodium alginate to HPMC.To determine content of indomethacin with UV spectrophotometic method and study on characteristics ... |
| Keywords: | Indomethacin Sodium alginate In situ gel ion-sensitive ophthalmic Quality control |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |
| 点击此处可从《医药导报》浏览原始摘要信息 | |
| 点击此处可从《医药导报》下载全文 | |