难治复发型小细胞肺癌的治疗进展

小细胞肺癌对一线治疗的有效率高 ,但是一种常见的易耐药和易复发的肿瘤。复发难治性SCLC治疗方案的选择 ,主要根据对一线治疗的有效率、治疗间隔的时间和疾病的进展情况来决定。KPS评分好 ,一线治疗 3个月后复发的患者治疗仍应用原来的方案 ;治疗早期进展或 3个月内复发的患者应选择无交叉耐药的新药物如紫杉醇、长春瑞滨、伊立替康、拓扑替康和健择等组成的新化疗方案 ;骨或脑转移通常给予放射治疗减轻症状。对胸腔内的复发、严重的大气道阻塞、上腔静脉综合征的患者也是放疗恰当的适应证。调强、适形放疗是一种新的放疗技术 ,新药和新放疗技术的应用给SCLC的治疗带来了希望

Advance in Treatment of Relapsed and Refratory Small Cell Lung cancer

Small cell lung cancer is a commonly relapsing tumor despite a high response after first-line chemotherapy.The choose of treatment at relapseing and refratory patients mainly depends on the response to first-line treatment,time off therapy and the site of progression.The patients with a relapse more than 3 months after first-line therapy rigment and a good performance status,the regiment is the same as initial therapy.In case of earlier progression,so-called non-cross-resistant new drug shuc as Paclitaxel?Vinorebine?Irinotecan?Topotecan and Gemcitabine should be given.For patients with symptomatic metastases in brain or bone,Radiotherapy should be given temporary palliation.For intrathoracic relapse severe obstraction of main bronchus and/or supeorior cavalvein radiotherapy is a effective therapy?Intensity-Modulated Radiation Therapy(IMRT) and 3D-CRT are the new technique of radiotherapy.New angents and new technique of radiotherapy will be hopeful for SCLC.