诱发颅内动脉瘤破裂的相关因素分析

目的分析诱发颅内动脉瘤破裂的相关危险因素.方法对80例颅内未破裂动脉瘤患者进行横断面式的随访调查.I组44例患者未经受蛛网膜下腔出血(SAH);II组36例患者脑动脉经受了SAH的刺激,手术已将破裂或较大、引发相关症状的动脉瘤夹闭,仍留有未破裂动脉瘤的多发动脉瘤患者.结果共随访到53例(66.3%).I组26例,目前年龄(到随访时)8.17～76.17岁,平均46.06岁,平均随访4.02人年;II组27例,目前年龄14.83～73.25岁、平均51.74岁,平均随访6.61人年.I组5例,出院后平均1.22年因动脉瘤破裂而死亡,破裂率4.79/100人年;1例椎动脉瘤患者,出院后2.25年瘤体从27 mm增大到34mm,动脉瘤发展率1.30/100人年.II组患者无死亡,1例随访2.42年时,发现一新增的基底动脉瘤,动脉瘤形成率0.56/100人年.结论诱发颅内动脉瘤破裂的危险因素有患者年龄、性别、首发症状以及动脉瘤大小、部位等.

Related factors of inducing intracranial aneurysms to rupture

Objective To analyze the related factors of affect in g intracranial aneurysms to rupture.Methods Eighty patients wit h unruptured intracranial aneurysm in this study were divided into two groups. F orty-four patients who had not suffered subarachnoid hemorrhage (SAH) were in Group I and had not been interferred by operation, while 36 patients who had been operated for hemorrhage or aneurysms with syndromes with unruptured intracr anial aneurysms were in Group II. Eighty patients were followed-up by letters a nd telephone from March to September, 2002.Results A total of 5 3 patients had been followed up. Among them, 26 in Group I had a male to female ratio of half to half. At present, their age ranged from 8.17 to 76.17 years wit h a mean age of 46.06. The mean period of follow-up was 4.02 persons year since discharging. Twenty-seven followed-up cases were in Group II with 7 males and 20 females. Their present age ranged from 14.83 to 73.25 years with a mean age of 51.74. The mean period of follow-up was 6.61 persons year since discharg ing. Five patients of Group I died of the rupture of aneurysms 1.22 years after discharging on the average. The annual rupture rate was 4.79 per 100 persons. A vertebral aneurysm enlarged from 27 to 34 mm in one patient of group I in 2.25 y ears after discharging. The annual rate of aneurysm enlarging was 1.30 per 1 00 persons year. None of Group II died of the rupture of aneurysms or cerebr al hemorrhage in other sites. A new basilar aneurysm developed in one patient of group II in 2.42 years after discharging. The annual rate of aneurysm developin g was 0.56 per 100 persons year. Conclusion The factors that have effect on the rupture of intracranial aneurysms include age, gender, sympt oms of patients, sizes and locations of aneurysms.