急性心肌梗死患者早期BNP测定的临床意义

目的　探讨急性心肌梗死早期BNP浓度的测定在评价左室重构、心功能状态及梗死预后的临床价值。方法　急性心肌梗死患者急性期和恢复期分别测定脑钠素 (BNP)浓度、左心室舒张末期容积指数(LVEDVI)、左室射血分数 (LVEF)及进行心功能Killip分级 ,将患者分别分为重构组与非重构组、LVEF≤ 4 0 %组与LVEF >4 0 %组、Killip(Ⅰ_Ⅱ )组与Killip(Ⅲ_Ⅳ )组、死亡组与非死亡组 ,进行BNP浓度的对比。结果　重构组、LVEF≤ 4 0 %组、Killip(Ⅲ_Ⅳ )组和死亡组BNP浓度显著高于非重构组 (P <0 0 0 1)、LVEF >4 0 %组 (P <0 0 0 1)、Killip(Ⅰ_Ⅱ )组 (P <0 0 0 1)和非死亡组 (P <0 0 1)。结论　血浆BNP水平是评价急性心肌梗死早期左室重构、心功能状态及梗死预后的敏感指标 ,具有一定的临床价值

The Clinical Significance of Plasma BNP concentration in Early Phase in Patients with Acute Myocardial Infarction

Objective To evaluate the clinical value of plasma concentration of brain natriutic peptide(BNP) in left ventricular remolding,status of heart function and prognosis in early phase of acute myocardial infarction(AMI). Methods The plasma concentration of BNP,LVEDVI,LVEF and heart function (according to Killip grade) were measured both in acute phase and in convalescent phase after AMI. Patients with AMI were divided into remolding group and non_remolding group;LVEF≤40% group and LVEF>40% group;Killip (Ⅰ_Ⅱ) group and Killip (Ⅲ_Ⅳ) group;death group and non_death group. Comparison was made in plasma BNP concentration among above groups,respectively. Results The plasma BNP concentration in remolding group,LVEF≤40% group,Killip (Ⅲ_Ⅳ) group and death group was significantly higher than that in non_remolding group,LVEF>40% group,Killip (Ⅰ_Ⅱ) group and non_death group. Conclusions Plasma BNP level was valuable in evaluating left ventricular remolding,status of heart function and prognosis in early phase in patients with AMI.