吡啶斯的明试验对评价垂体hGH储备功能的价值

垂体hGH分泌受中枢神经介质调控。兴奋胆碱能系统可使hGH增加。本文试用胆碱酯酶抑制剂吡啶斯的明兴奋hGH,并与胰岛素兴奋试验进行比较,观察了13名正常青少年和10名垂体性侏儒症患者对两种兴奋试验的反应。结果显示口服吡啶斯的明2mg/kg体重能迅速有效地兴奋垂体hGH释放。其作用较胰岛素兴奋试验更强,是一项值得推荐的判定青少年垂体hGH储备功能的试验。

Human growth hormone response to pyridostigmine in normal and hGH deficient adolescents

There is evidence indicating that the cholinergic system positively modulates HGH secretion. In the present study, we observed the effects of cholinergic enhancement by pyridostigmine (PD), a cholinesterase inhibitor, on hGH release in both normal (n=13) and hGH deficient (n=10) adolescents. Responses of hGH to insulin hypoglycemia (Ins) were also observed. In normal subjects, PD-induced serum hGH peak levels were significantly higher than that induced by Ins (P<0.01). By contrast, the hGH level in the patients with pituitary dwarfism showed no increase by both" tests. The study indicates that PD test may be considered a useful dyanamic test in evaluating pituitary function of hGH secretion in children and adolescents.