Knockout of the aryl hydrocarbon receptor results in distinct hepatic and renal phenotypes in rats and mice |
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| Authors: | Joshua A. Harrill Renee R. Hukkanen Marie Lawson Greg Martin Brian Gilger Valerie Soldatow Edward L. LeCluyse Robert A. Budinsky J. Craig Rowlands Russell S. Thomas |
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| Affiliation: | 1. The Hamner Institute for Health Sciences, Institute for Chemical Safety Sciences, RTP, NC 27709, USA;2. The Dow Chemical Company, Midland, MI 48640, USA;3. North Carolina State University, College of Veterinary Medicine, Raleigh, NC 27606, USA;4. University of North Carolina, Department of Environmental Sciences and Engineering, Chapel Hill, NC 27599, USA |
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| Abstract: | |
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| Keywords: | AHR, aryl hydrocarbon receptor AHR-KO, aryl hydrocarbon receptor knockout Ahrr, aryl hydrocarbon receptor repressor AIP, aryl hydrocarbon receptor interacting protein ALB, serum albumin ALP, alkaline phosphatase ALT, alanine aminotransferase ARNT, aryl hydrocarbon receptor nuclear translocator AST, aspartate aminotransferase BLO, urine occult blood BUN, blood urea nitrogen BAS, basophils BILI, urine bilirubin CA, calcium CAOX, calcium oxalate crystals CBC, complete blood count CHOL, cholesterol CL, chloride CREA, creatinine CYP1A1, cytochrome P450, family 1, subfamily A, polypeptide 1 CYP1A2, cytochrome P450, family 1, subfamily A, polypeptide 2 CYP1B1, cytochrome P450, family 1, subfamily B, polypeptide 1 DRE, dioxin-response element EOS, eosinophils EPI, urine epithelial cells GGT, γ-glutamyl transpeptidase GLOB, serum globulin GLUC, serum glucose HB, hemoglobin HBSS, Hank's Balanced Salt Solution HCT, hematocrit HSP90, 90-kDa heat shock protein K, potassium KET, urine ketones LD50, median lethal dose LEUC, leukocytes LYM, lymphocytes MCH, mean corpuscular hemoglobin MCHC, mean corpuscular hemoglobin concentration MCV, mean corpuscular volume MON, monocytes NA, sodium NEU, neutrophils PHOS, phosphorus PLT, platelets RBC, red blood cells SG, urine specific gravity TBA, total bile acid TBIL, total bilirubin TCDD, 2,3,7,8-tetracholorodibenzo-p-dioxin TP, total serum protein TPHO, triple phosphate crystals TRIG, triglycerides UBIL, urine bilinogen UGLU, urine glucose ULEUC, urine leukocytes UPRO, urine protein URBC, urine red blood cells UWBC, total white blood cells WT, wild-type ZFN, zinc finger nuclease |
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