乌拉地尔预防无抽搐电体克致老年精神病患者心血管反应对照研究

目的探讨无抽搐电休克治疗前静脉注射乌拉地尔预防老年精神病患者心血管反应的临床效果。方法将行无抽搐电休克治疗的71例老年精神病患者随机分为两组，研究组36例，对照组35例，研究组无抽搐电休克治疗前静脉注射乌拉地尔。于无抽搐电休克治疗麻醉前、麻醉后、刺激时、刺激后2min、6min、10min、15min末分别记录两组心率、收缩压、舒张压、平均动脉压，计算各时点的心率与收缩压乘积，评价心血管反应。结果研究组无抽搐电休克治疗麻醉后、刺激时、刺激后2min、6min、10min末心率、心率与收缩压乘积及刺激时、刺激后2min末收缩压、舒张压、平均动脉压均显著高于麻醉前（P〈0．01），对照组麻醉后心率、心率与收缩压乘积及刺激时、刺激后2min、6min、10min末收缩压、舒张压、平均动脉压均显著高于麻醉前（P〈0．05）；但研究组刺激时、刺激后2min、6min、10min末均显著低于对照组（P〈0．01），而麻醉前后及刺激后15min末与对照组无显著差异（P〉0．05）。结论无抽搐电休克治疗麻醉前静脉注射乌拉地尔能减轻或缓解应激性生理变化导致的心血管反应。

Preliminary urapidil injection controling cardiovascular response to MECT in senile patients

Objective To study preliminary urapidil injection controling cardiovascular response to MECT in senile patients. Methods 71 senile patients receiving MECT were randomly divided into research group （n=36） with preliminary urapidil injection and control group （n=35） without, then anesthetized and treated; timepoint HR,SBP, SDP and MAP were recor n ded and at the 2nd ,6th ,10th and 15th minute after stimulation, before and after anesthesia, during stimulation cross product of HR and SBP computed to estimate oxygen consumption of myocardium（RPP）, and data treated with SPSS12.0 software. Results There were no differnces in in all data before and after anesthesia between the 2 groups（P〉0.05） ; above- mentioned data were significantly lower in the research than in the control group during stimulation and at the 2nd,6th and 10th minute （P〈0.05） and there was no difference at 15th minute（P〉0.05）; intragroup comparisons showed that the data were higher during anesthesia and at the 2nd minute after anesthesia in the research group（P〈0.05） and during anesthesia and at the 2nd ,6th and 10th minute in the control group （P〈0.05） compared with preanesthesia,and there was no difference at the 15th minute（P〉0.05）. Conclusion Preliminary urapidil injection may obviously control cardiovascular response to MECT in senile patients.