| 维生素E、牛黄酸等抗氧化剂对博莱霉素致突变性的拮抗作用 |
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| 引用本文： | 宗传龙,周白云,郭淼,刘景升,李效良. 维生素E、牛黄酸等抗氧化剂对博莱霉素致突变性的拮抗作用[J]. 泰山医学院学报, 2004, 25(1): 52-54 |
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| 作者姓名： | 宗传龙 周白云 郭淼 刘景升 李效良 |
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| 作者单位： | 泰山医学院,山东,泰安,271000 |
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| 摘 要： | 目的观察抗氧化剂(维生素E、牛黄酸、二甲亚砜和维生素C)针对博莱霉素(Bleomycin,BLM)的拮抗作用.方法在人外周血淋巴细胞培养物中注入一定剂量的BLM并一定剂量的抗氧化剂,然后观察淋巴细胞的姐妹染色单体交换率(sisterchromatid exchanges,SCE rate)的变化.结果维生素E浓度为5μl/ml时,可显著地拮抗BLM(28.6nmol/ml)的致突变作用(P＜0.05);而维生素E浓度为10μl/ml时,可极显著地拮抗BLM的作用(P＜0.01);当加入牛黄酸的终浓度为100和200μg/rl时,均可显著地拮抗BLM(28.6nmol/m1)的致突变作用(P＜0.05).结论一定剂量的维生素E和牛黄酸对BLM的致突变性存在着拮抗作用.
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| 关 键 词： | 博莱霉素 维生素E 牛黄酸 二甲亚砜 维生素C |
Antagonistic effect of vitamin E and taurine on mutagenesis of bleomycin |
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| ZONG Chuan-long,ZHOU Bai-yun,GUO Miao,LIU Jing-sheng,LI Xiao-liang. Antagonistic effect of vitamin E and taurine on mutagenesis of bleomycin[J]. Journal of Taishan Medical College, 2004, 25(1): 52-54 |
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| Authors: | ZONG Chuan-long ZHOU Bai-yun GUO Miao LIU Jing-sheng LI Xiao-liang |
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| Abstract: | Objective: To observe antagonistic effect of vitamin E, taurine and some other antioxidants on mutagenesis of bleomycin. Methods: The changes of SCE (sister chromatid exchanges) rates of human blood lymphocytes were observed when vitamin E and taurine had been added into the culture medium for human blood lymphocytes. Results: Vitamin E(5μl/ml)or taurine(100 or 200μg/ml) had a significant effect on lowering SCE of lymphocytes treated by BLM(28.6 nmol/rml) (P ＜0.05); While vitamin E( 10μl/ml) has a very significant effect on lowering SCE of lymphocytes treated by BLM(28.6 nmol/ml) (P ＜0.01). Conclusion: A certain dosage of either vitamin E or taurine has a significant effect on antagonizing mutagenesis of BLM by lowering SCE of human blood lymphocytes. |
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| Keywords: | bleomycin vitamin E taurine dimethylsulfoxide vitamin C |
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