Mapping the Von Hippel -- Lindau disease tumour suppressor gene: identification of germline deletions by pulsed field gel electrophoresis |
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Authors: | Richards Frances M; Phipps Maude E; Latlf Farida; Yao Masahlro; Crossey Paul A; Foster Kelth; Llnehan W Marston; Affara Nabeel A; Lerman Michael I; Zbar Berton; Ferguson-Smith Malcolm A; Maher Eamonn R |
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Institution: | Cambridge University Department of Pathology Cambridge, UK
1Laboratory of Immunobiology, National Cancer Institute-Fredenck Cancer Research Facility Fredenck
2Surgery Branch, National Cancer Institute USA |
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Abstract: | Von HlppelLindau (VHL) disease is a dominantly Inheritedfamillal cancer syndrome In which affected individuals havea greatly increased predisposition to the development of haemangloblastomasof the central nervous system and retina, renal cell carcinomaand phaeochromocytoma. The VHL gene has been mapped to chromosome3p25 -p26 by genetic linkage studies and we have previouslydemonstrated that the VHL gene is tightly linked to the D3S601locus (Zmax = 18.86 at |
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