Mapping the Von Hippel -- Lindau disease tumour suppressor gene: identification of germline deletions by pulsed field gel electrophoresis期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Mapping the Von Hippel -- Lindau disease tumour suppressor gene: identification of germline deletions by pulsed field gel electrophoresis

Authors:	Richards Frances M; Phipps Maude E; Latlf Farida; Yao Masahlro; Crossey Paul A; Foster Kelth; Llnehan W Marston; Affara Nabeel A; Lerman Michael I; Zbar Berton; Ferguson-Smith Malcolm A; Maher Eamonn R

Institution:	Cambridge University Department of Pathology Cambridge, UK ¹Laboratory of Immunobiology, National Cancer Institute-Fredenck Cancer Research Facility Fredenck ²Surgery Branch, National Cancer Institute USA

Abstract:	Von Hlppel—Lindau (VHL) disease is a dominantly Inheritedfamillal cancer syndrome In which affected individuals havea greatly increased predisposition to the development of haemangloblastomasof the central nervous system and retina, renal cell carcinomaand phaeochromocytoma. The VHL gene has been mapped to chromosome3p25 -p26 by genetic linkage studies and we have previouslydemonstrated that the VHL gene is tightly linked to the D3S601locus (Zmax = 18.86 at

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