| 甲硝唑琥珀酸酯在兔体内的药动学 |
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| 引用本文： | 杜智敏,刘影,张波,曲福军.甲硝唑琥珀酸酯在兔体内的药动学[J].中国药学杂志,2004,39(10):780-781. |
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| 作者姓名： | 杜智敏 刘影 张波 曲福军 |
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| 作者单位： | 1. 哈尔滨医科大学附属第二医院临床药物研究所,黑龙江,哈尔滨,150086
2. 哈尔滨医科大学药理室,黑龙江,哈尔滨,150086 |
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| 摘 要： | 目的 研究甲硝唑前体药物甲硝唑琥珀酸酯在兔体内的药动学特性。方法 用HPLC测定甲硝唑琥珀酸酯在生物样品 中的浓度。结果 血浆中内源性杂质不干扰甲硝唑的测定,血浆中回收率为98.63％,日内和日间RSD分别为2.6％和3.7％, 最低检出浓度为0.1μg·mL-1。结论 甲硝唑琥珀酸酯在兔体内能迅速水解,且不改变甲硝唑原有的药动学特性。
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| 关 键 词： | 甲硝唑琥珀酸酯 甲硝唑 药动学 高效液相色谱法 |
| 文章编号： | 1001-2494(2004)10-0780-02 |
| 收稿时间： | 2003-07-11; |
Pharmacokinetics of metronidazole-succinate in rabbits |
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| DU Zhi-min,LIU Ying,ZHANG Bo,QU Fu-jun.Pharmacokinetics of metronidazole-succinate in rabbits[J].Chinese Pharmaceutical Journal,2004,39(10):780-781. |
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| Authors: | DU Zhi-min LIU Ying ZHANG Bo QU Fu-jun |
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| Institution: | 1.Institute of Clinical Pharmacy and Pharmacology,Second Affiliated Hospital,Harbin Medical University,Harbin 150086,China;2.Department of Pharmacology,Harbin Medical Uviversity,Harbin 150086,China |
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| Abstract: | OBJECTIVE To study the pharmacokinetic profile of metronidazole-succinate in rabbits.METHODS Metronidazole-succi-nate concentrations were determined by HPLC method. RESULTS The determination of metronidazole-succinate was not interfered by the impurities in plasma.The recovery of metronidazole in plasma was 98.63% .The precisions of intra-day and inter-day were 2.6% and 3.7% respectively. The limit of detection was 0.1 μg·mL-1 .CONCLUSION Metronidazole-succinate was hydrolyzed into metronidazole in rabbits rapidly.The pharmacokinetic profile of metronizole showed no difference. |
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| Keywords: | mertonidazole-succinate metronidazole praimacokinetics HPLC |
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