血液病合并血流感染患者的病原菌分布及药敏分析

目的了解血液病合并血流感染患者的病原菌分布及药敏情况。方法对835例血液病患者的血培养及药敏结果进行回顾性分析。结果从835份血培养标本中共检出56株（6．7％）致病菌，其中革兰阴性杆菌34株（60．7％），包括大肠埃希菌15株，沙门氏菌9株，肺炎克雷伯菌4株，其他细菌6株，最敏感的药物是亚胺培南、厄他培南；革兰阳性球菌21株（37．5％），包括凝固酶阴性葡萄球菌9株，肠球菌7株，链球菌3株，金黄色葡萄球菌2株，最敏感的药物是万古霉素、呋喃妥因、复方新诺明；真菌1株，为念珠菌。结论革兰阴性杆菌仍是血液病并发血流感染患者的主要病原菌，对药物的耐药率明显升高，临床医师应根据药敏结果合理选择抗菌药物进行治疗，以减少和控制细菌的耐药性。

Analysis of distribution and drug sensitivity of pathogenic bacteria in bloodstream infection of patients with hematologic diseases

Objective To investigate distribution and drug sensitivity of pathogenic bacteria in bloodstream infection of patients with hematologic diseases. Methods A retrospective analysis of distribution and drug sensitivity of pathogenic bacteria from blood ctdture were performed on 835 patients with hematologic diseases. Results Totally 56 strains（ 6.7% ） of pathogens were isolated from 835 clinical blood specimens, among which there were 34 strains （60. 7% ） Gram-negative bacteria consisted of 15 strains Escherichia coli,9 strains Salmonella,4 strains klebsilla pneumoniae were sensitive to imipenem, ertapenem; 21 strains （37.5%） Gram-positive bacteria consisted of 9 strains coagulase negative staphylococcus,7 strains enterococus,3 strains streptococcus were sensitive to vancomycin,nitro- furantoin,eompound Sul famethoxazole; 1 strain fungus Was monilia. Conclusion Gram-negative bacteria was still main pathogenic bacteria in bloodstream infection of patients with hematologic diseases, which are highly resistant to antibacterial drugs. So clinical doctors should rationally select antibiotics in the treatment according to drug sensitivity results, so as to reduce and control drug resistance.